Sökning: "Predictive Modelling"

Visar resultat 6 - 10 av 156 avhandlingar innehållade orden Predictive Modelling.

  1. 6. Computational Modelling of Structures and Ligands of CYP2C9

    Författare :Lovisa Afzelius; Collen Masimirembwa; Ismael Zamora; Anders Karlén; Marcel de Groot; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; CYP2C9; 3D QSAR; GRID; CYP450; pharmacophore modelling; homology modelling; metabolism; competitive inhibitors; CPCA; molecular dynamics simulations; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; läkemedelskemi;

    Sammanfattning : CYP2C9 is one of our major drug metabolising enzymes and belongs to the cytochrome P450 (CYP) super family. The aim of this thesis was to gain an understanding of the quantitative structure–activity relationships (QSAR) of CYP2C9 substrates and inhibitors. LÄS MER

  3. 7. Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel

    Författare :Anja Henningsson; Mats O. Karlsson; Lena Friberg; Iñaki F. Trocóniz; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Mechanism-based; Modelling; Myelosuppression; Paclitaxel; Cremophor EL; NONMEM; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Sammanfattning : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. LÄS MER

  4. 8. Computational modelling in systems biology: from rewriting cell fates to detecting tumours

    Författare :Emil Andersson; Centrum för miljö- och klimatvetenskap (CEC); []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Beräkningsmodeller; Systembiologi; Genreguleringsnätverk; Cellomprogrammering; Energilandskap; iPSC; Agentbaserad modellering; T-cellsutveckling; Maskininlärning; Tumördiagnostik; Computational modelling; Systems biology; Gene regulatory network; Cell reprogramming; Energy landscape; iPSC; Agent-based modelling; Multi-scale modelling; T-cell development; Machine learning; Tumour diagnostics;

    Sammanfattning : Computational modelling is becoming an increasingly important tool in biological research. By performing computer simulations of models, it becomes possible to test theories about a biological system against experimental data. Simulations can also be used as a replacement for experiments otherwise unattainable. LÄS MER

  5. 9. Applied Machine Learning in Steel Process Engineering : Using Supervised Machine Learning Models to Predict the Electrical Energy Consumption of Electric Arc Furnaces

    Författare :Leo Carlsson; Pär Jönsson; Peter Samuelsson; Mikael Vejdemo-Johansson; Henrik Saxen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Electric Arc Furnace; Electrical Energy Consumption; Statistical Modelling; Machine Learning; Interpretable Machine Learning; Predictive Modelling; Industry 4.0; Ljusbågsugn; Elenergiförbrukning; Statistisk Modellering; Maskininlärning; Tolkningsbar Maskininlärning; Prediktiv Modellering; Industri 4.0; Teknisk materialvetenskap; Materials Science and Engineering; Metallurgical process science; Metallurgisk processvetenskap;

    Sammanfattning : The steel industry is in constant need of improving its production processes. This is partly due to increasing competition and partly due to environmental concerns. One commonly used method for improving these processes is through the act of modeling. LÄS MER

  7. 10. Predictive Modelling to Support Design and Manufacturing in Aerospace Engineering

    Författare :Siva Krishna Dasari; Abbas Cheddad; Lars Lundberg; Stan Matwin; Blekinge Tekniska Högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; surrogate modelling; defects classification; machine learning; aerospace; additive manufacturing; Computer Science; Datavetenskap;

    Sammanfattning : A crucial issue in the design of aircraft components is the evaluation of a large number of potential design alternatives.  This evaluation involves too expensive procedures, consequently, it slows down the search for optimal design samples. LÄS MER