Sökning: "Pre-clinical imaging"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden Pre-clinical imaging.

  1. 16. Generation and engineering of ABD-derived affinity proteins for clinical applications

    Författare :Sarah Lindbo; Sophia Hober; Christoph Rader; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; ABD; ADAPT; affinity proteins; protein engineering; radionuclide molecular imaging; HER2; Bioteknologi; Biotechnology;

    Sammanfattning : Proteins that specifically recognize and bind to other molecules or structures are important tools in industrial and medical applications. Binding proteins engineered from small stable scaffold proteins have been utilized for several purposes due to their favorable biophysical properties, tolerance to mutagenesis, efficient tissue penetration and ease of production. LÄS MER

  3. 17. Methodological developments in small animal PET neuroimaging

    Författare :Miklós Tóth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Positron emission tomography (PET) is a nuclear imaging technique using a multidisciplinary approach to functionally visualize processes in the brain or other living tissue. It is capable to determine the pharmacokinetic and pharmacodynamic properties of a molecule in the CNS, with a low risk of side effects on the subject. LÄS MER

  4. 18. Theranostics in radiology : development of targeted contrast media with treatment capability

    Författare :Åsa Barrefelt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Imaging is essential in the diagnostics and medicine of today. The development of new contrast agents is important for obtaining specific information from images and to distinguish disease. Microbubbles (MB) have previously been introduced as a contrast agent for ultrasound. LÄS MER

  5. 19. Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI

    Författare :Nils Dahlström; Örjan Smedby; Torkel Brismar; Anders Ynnerman; Carsten Thomsen; Linköpings universitet; []
    Nyckelord :Liver; spleen; hepatobiliary system; liver function; MRI; DCE-MRI; Gd-EOBDTPA; Gd-BOPTA; pharmacokinetic; hepatocyte; relaxivity.; MEDICINE; MEDICIN;

    Sammanfattning : The studies presented here evaluate the biliary, parenchymal and vascular enhancement effects of two T1-shortening liver-specific contrast agents, Gd-BOPTA and Gd-EOB-DTPA, in Magnetic Resonance Imaging (MRI) of healthy subjects and of patients.Ten healthy volunteers were examined with both contrast agents in a 1. LÄS MER

  7. 20. Human embryonic stem cells for retinal repair : preclinical in vitro and in vivo studies for the treatment of age-related macular degeneration with human embryonic stem cell-derived retinal pigment epithelial cells

    Författare :Sandra Petrus-Reurer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Age-related macular degeneration (AMD) is the major cause of vision loss in the industrialized countries in people above sixty years of age. The dry advanced form of the disease, also termed as geographic atrophy (GA), is characterized by the progressive death of retinal pigment epithelial cells (RPE) and consequent loss of the adjacent photoreceptor (PR) layer, leading to an impaired visual function. LÄS MER