Sökning: "Potency"

Visar resultat 16 - 20 av 248 avhandlingar innehållade ordet Potency.

  1. 16. Structure and Activity of Circular Plant Proteins : Cytotoxic Effects of Viola Cyclotides

    Författare :Anders Herrmann; Ulf Göransson; Lars Bohlin; Douglas Kinghorn; Uppsala universitet; []
    Nyckelord :Pharmacognosy; cyclotide; cytotoxic; anti-tumour; macrocyclic; cyclic cystine knot; Alpine violet; Sweet violet; Viola; Violaceae; chemical modifications; structure-activity studies; mass spectroscopy; cDNA clones; Farmakognosi;

    Sammanfattning : Cyclotides are a family of small and macrocyclic proteins that have been found in Violacaee and Rubiaceae plant species. These proteins contain a cystine knot: two disulfides bonds together with their connecting peptide backbone form an embedded ring which is penetrated by a third disulfide bond. LÄS MER

  3. 17. Physico-chemical characteristics and quantitative structure-activity relationships of PCBs

    Författare :Patrik Andersson; Stephen Safe; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; polychlorinated biphenyls; PCBs; physico-chemical properties; statistical design; multivariate; PCA; PLS; biomagnification; BMF; bioassay; CYP1A; SAR; QSAR; REPs; risk assessment; Chemistry; Kemi; Chemistry; Kemi;

    Sammanfattning : The polychlorinated biphenyls (PCBs) comprise a group of 209 congeners varying in the number of chlorine atoms and substitution patterns. These compounds tend to be biomagnified in foodwebs and have been shown to induce an array of effects in exposed organisms. LÄS MER

  4. 18. Voltage sensitivity of dopamine D2-like receptors

    Författare :Kristoffer Sahlholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands. LÄS MER

  5. 19. Emotional facial processing in younger and older adults

    Författare :Joakim Svärd; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : There is evidence that older adults have difficulty processing negative but not positive facial expressions. This positivity effect among older adults is expressed in attention to as well as in memory and recognition of emotional faces. In the present thesis, effects of stimulus properties (i.e. LÄS MER

  7. 20. Improved CoMFA Modeling by Optimization of Settings : Toward the Design of Inhibitors of the HCV NS3 Protease

    Författare :Shane Peterson; Anders Karlén; Anja Sandström; Ulf Norinder; Uppsala universitet; []
    Nyckelord :Pharmaceutical chemistry; CoMFA; 3D-QSAR; model validation; Docking; SAR; hepatitis C virus; HCV; NS3 protease inhibitor; Farmaceutisk kemi;

    Sammanfattning : The hepatitis C virus (HCV), with a global prevalence of roughly 2%, is among the most serious diseases today. Among the more promising HCV targets is the NS3 protease, for which several drug candidates have entered clinical trials. LÄS MER