Sökning: "Potassium channel openers"

Hittade 2 avhandlingar innehållade orden Potassium channel openers.

1. 1. A study of potassium channel activation as a pharmacological principle for vasodilation of cerebral blood vessels

   Författare :Torsten Ryman; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacological sciences; cerebral arteries; Cerebral ischemia; Potassium channel openers; vascular endothelium; EDHF; KRN2391; KATP; Pinacidil; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : Increasing [K+]o is intimately coupled to progressive ischemia and reduced CBF. In isolated cerebral and mesenteric arteries, it was found that significant differences in the vascular responses to [K+]o exist. Among the species studied, human cerebral arteries were the most sensitive artery to increasing [K+]o. LÄS MER

3. 2. Molecular Mechanisms of Resin Acids and Their Derivatives on the Opening of a Potassium Channel

   Författare :Nina Ottosson; Fredrik Elinder; David Engblom; Bertil Hille; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Voltage-gated ion channels play fundamental roles in excitable cells, such as neurons, where they enable electric signaling. Normally, this signaling is well controlled, but brain damage, alterations in the ionic composition of the extracellular solution, or dysfunctional ion channels can increase the electrical excitability thereby causing epilepsy. LÄS MER