Sökning: "Post-transcriptional regulation"
Visar resultat 16 - 20 av 82 avhandlingar innehållade orden Post-transcriptional regulation.
16. Transcriptional and post-transcriptional regulation of vascular smooth muscle cell phenotype - Implications for vascular disease states
Sammanfattning : As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. LÄS MER
17. Molecular Cloning and Functional Characterization of Factors Involved in Post-transcriptional Gene Expression
Sammanfattning : Gene expression in the eukaryotic cell is a fundamental cellular process, which consists of several distinct steps but extensively coupled to each other. From site of transcription in the nucleus to the cytoplasm, both mRNA and rRNA are associated with a proper set of proteins. LÄS MER
18. Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
Sammanfattning : Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA elongation, is silent in most normal differentiated human cells due to the tight repression of its catalytic unit, telomerase reverse transcriptase (hTERT), whereas constitutive hTERT expression and telomerase activation are prerequisites for cellular immortalization/malignant transformation. As reconfiguration of chromatin acts like a master on/off switch, determining whether particular genes are active or inactive, the project was specifically designed to first elucidate molecular strategies that integrate diverse signalling pathways at the hTERT chromatin and consequently result in telomerase activation or repression in normal and malignant human cells. LÄS MER
19. RNA-based mechanisms of chromatin and gene regulation
Sammanfattning : Cells regulate gene expression in a particular spatio-temporal manner by executing specific transcriptional programs. The different transcriptional programs allow the generation of the different cell types in multicellular organisms and mediate particular cellular responses to external cues such as viral infections. LÄS MER
20. YopD translocator function in Yersinia pseudotuberculosis type III secretion
Sammanfattning : Type III secretion systems (T3SS) are a common feature of Gram-negative bacteria, allowing them to inject anti-host effectors into the interior of infected eukaryotic cells. By this mechanism, these virulence factors help the bacteria to modulate eukaryotic cell function in its favor and subvert host innate immunity. LÄS MER