Sökning: "Polymorphisms"
Visar resultat 21 - 25 av 557 avhandlingar innehållade ordet Polymorphisms.
21. Effect of genetic polymorphisms on urinary bladder neoplasms
Sammanfattning : Urinary bladder neoplasms (UBNs) are among the most common malignancies in the world and are mainly attributed to exogenous risk factors such as, smoking, exposure to industrial aromatic amines and certain medicinal drugs which cause DNA damage. The entire process leading to DNA damage and subsequent repair of the damage involves a plethora of enzymes including those involved in metabolic and DNA repair processes. LÄS MER
22. Understanding evolutionary novelty through female-limited polymorphisms
Sammanfattning : Understanding how novel traits evolve is a central question in evolutionary biology. However, unraveling the complex genetic and developmental mechanisms underlying trait innovation can be challenging, especially when the trait evolved a long time ago. LÄS MER
23. CYP2C19 polymorphisms in drug metabolism and response
Sammanfattning : Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience adverse effects. LÄS MER
24. Significance of polymorphisms in human xenobiotic metabolising enzymes
Sammanfattning : Cigarette smoke is the primary cause of lung cancer but urban air pollution and certain occupational exposures have also been found to elevate the incidence of lung cancer. These exposures contain polycyclic aromatic hydrocarbons (PAH), which can be metabolically activated to highly reactive compounds capable of binding to DNA and initiating the carcinogenic process unless they are eliminated. LÄS MER
25. Inflammasome polymorphisms and the Inflammatory Response to Bacterial Infections
Sammanfattning : NLRP3 inflammasome; a key component of the innate immune system, can be activated by a number of pathogens and other threats of the body. Activation of the NLRP3 inflammasome triggers caspase-1 mediated maturationof IL-1β and IL-18. LÄS MER