Sökning: "Polymorphisms"

Visar resultat 16 - 20 av 557 avhandlingar innehållade ordet Polymorphisms.

1. 16. Interaction between dietary factors and genetic risk for lipoprotein traits and cardiovascular disease

   Författare :Sophie Hellstrand; Diabetes - kardiovaskulär sjukdom; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diet; polyunsaturated fatty acids; diet quality index; fatty acid desaturase; blood lipids; lipoproteins; polymorphisms; genetic risk score; gene-diet interaction; cohort; epidemiology; cardiovascular disease;

   Sammanfattning : In previous studies, a high quality diet has been associated with a reduced risk of cardiovascular disease (CVD) compared to a low diet quality, and specific “healthy” diet components, such as polyunsaturated fatty acids (PUFAs), have been hypothesized to reduce the risk of CVD. However, results from epidemiological studies have been conflicting. LÄS MER

3. 17. Exposure, health effects, immunological markers and biomarkers of susceptibility among Swedish rubber workers

   Författare :Lena S Jönsson; Avdelningen för arbets- och miljömedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yrkesmedicin; arbetsmiljömedicin; industrial medicine; Public health; epidemiology; Folkhälsa; epidemiologi; Occupational health; Andningsorganen; rubber industry; polymorphisms; vulcanisation fumes; Respiratory system; nausea; headache; exposure-response relationships; biomarkers; symptoms; airways; eyes; TTCA; PAH; 1-hydroxypyrene;

   Sammanfattning : Workers in the rubber industry have an increased risk of several diseases, such as airway disease, cancer and probably cardiovascular disease. The exposure is very complex; carbon disulfide (CS2) and polycyclic aromatic hydrocarbons (PAHs) being two of the contaminants. LÄS MER

4. 18. Influence of host genetics on innate immunity and susceptibility to urinary tract infection

   Författare :Bryndis Ragnarsdottir; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; IRF3; Innate Immunity; urinary tract infections; acute pyelonephritis; asymptomatic bacteriuria; Toll-like receptor 4; CXCR1; TLR4 adaptors; polymorphisms;

   Sammanfattning : It has been known for a long time that the clinical manifestations of urinary tract infections (UTI) differ markedly between individuals, ranging from a sometimes beneficial, asymptomatic state to life threatening infections. This variability in clinical manifestation can be explained in part by the arsenal of virulence factors of the bacteria but the predisposition of the patient is equally important. LÄS MER

5. 19. Immune regulation of herpes simplex virus type 2 infection: Special emphasis on the transcription factor T-bet

   Författare :Alexandra Svensson; Göteborgs universitet; []
   Nyckelord :HSV-2; T-bet; Substance P; Neurokinin 1; IFN-alfa beta signaling; Polymorphisms;

   Sammanfattning : Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract mucosa as well as local sensory neurons. It is the most common cause of genital ulcer disease in humans. The infection gives rise to a wide range of symptoms, ranging from severe and painful recurrent episodes of genital herpes to silent infection. LÄS MER

7. 20. Clinical Pharmacogenetics of Olanzapine : with Focus on FMO Gene Polymorphisms

   Författare :Mao Mao Söderberg; Marja-Liisa Dahl; Maria Gabriella Scordo; Inger Johansson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; olanzapine; pharmacogenetics; drug metabolism; schizophrenia; therapeutic drug monitoring; FMO1; FMO3; CYP1A2; UGT1A4; Clinical Pharmacology; Klinisk farmakologi;

   Sammanfattning : Pharmacogenetics is the study of variability in drug response attributed to genetic variation. Olanzapine (OLA) is a widely used antipsychotic drug for schizophrenia treatment. The pharmacokinetics of OLA display large inter-individual variation leading to multiple-fold differences in drug exposure between patients at a given dose. LÄS MER