Sökning: "Plasmodium falciparum erythrocyte membrane protein 1"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden Plasmodium falciparum erythrocyte membrane protein 1.

1. 1. Carbohydrate-mediated adhesion in Plasmodium falciparum malaria

   Författare :Antonio Barragan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Plasmodium falciparum; malaria; erythrocyte rosetting; humoral immunity; glycosaminoglycan; heparan sulfate; heparin; ABO blood groups; Plasmodium falciparum erythrocyte membrane protein 1; var genes;

   Sammanfattning : Characterization of virulence factors in P. falciparum malaria is essential in order to identify new therapeutic and prophylactic targets. Rosette formation, the binding of uninfected red blood cells to parasite-infected red blood cells, is a P. falciparum virulence phenotype associated with severe clinical manifestations, e. LÄS MER

3. 2. Development of a recombinant protein vaccine against Plasmodium falciparum malaria

   Författare :Sanjay Ahuja; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Vaccine; Plasmodium falciparum; DBL1alpha ; cross-reactivity; E.coli; recombinant expression; soluble protein;

   Sammanfattning : Malaria, caused by Plasmodium falciparum is one of the world´s deadliest diseases, killing one to two million children, while another 500 million suffer from clinical attacks every year. Infections caused by P. LÄS MER

4. 3. Host cell adhesion of Plasmodium falciparum-infected erythrocytes

   Författare :Carl Johan Treutiger; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Plasmodium falciparum; erythrocyte rosetting; cytoadherence; cerebral malaria; PfEMPI; serum proteins; PECAM-I CD31;

   Sammanfattning : Excessive binding of Plasmodium falciparum-infected erythrocytes to the microvascular endothelium (cytoadherence) and to uninfected eryrthrocytes (rosetting) are regarded as key-events in the development of a severe malaria infection. P. falciparum rosetting was confirmed to be associated with the development of cerebral malaria in The Gambia. LÄS MER

5. 4. Heparan sulfate dependent sequestration during Plasmodium falciparum malaria

   Författare :Anna Vogt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Severe malaria; Plasmodium falciparum; sequestration; endothelial adhesion; erythrocyte rosetting; PfEMP1; DBL1alpha; heparan sulfate; heparin; animal model.;

   Sammanfattning : Plasmodium falciparum infected erythrocytes are able to bind to the microvascular endothelium (cytoadherence), and to uninfected erythrocytes (rosetting) that lead to excessive sequestration of the parasites. This causes obstruction of the deep microvasculature by P. LÄS MER

7. 5. Towards understanding the SURFIN protein family and var genes in Plasmodium falciparum

   Författare :Fingani Annie Mphande; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Plasmodium falciparum, the parasite responsible for severe malaria, has been shown to use different protein families for its survival and proliferation within the human host. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a protein responsible for the cytoadherence of parasitized red blood cells (pRBCs) has been implicated in severe disease. LÄS MER