Sökning: "Plasma clot"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden Plasma clot.

  1. 1. The Plasma Contact System : New Functional Insights from a Hemostatic and Thrombotic Perspective

    Författare :Jennie Bäck; Bo Nilsson; Kristina Nilsson Ekdahl; Ulla Hedner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Contact activation; factor XII; platelets; coagulation; antithrombin; C1 inhibitor; hemostasis; biomarkers; vascular disease.; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : The physiological role of the plasma contact system still remains a partial enigma. The aim of the presented work was to expand our understanding of the plasma contact system, focusing on its physiological activation and function, principally from a hemostatic perspective. It also explored contact system activation under pathological conditions. LÄS MER

  3. 2. Plasminogen Activator Inhibitor 1 in Platelets - Studies of Synthesis, Activity, and Glycosylation Patterns

    Författare :Helén Brogren; Göteborgs universitet; []
    Nyckelord :PAI-1; platelets; plasma; fibrinolysis; synthesis; polymorphism; glycosylation; activity; platelet mRNA;

    Sammanfattning : Plasminogen activator inhibitor 1 (PAI-1) is the main physiological inhibitor of tissue-type plasminogen activator. Thus PAI-1 plays an important role in decreasing the fibrinolytic activity in human blood. PAI-1 is present in high concentrations in platelets and also in low concentrations in plasma, but the source of plasma PAI-1 is not known. LÄS MER

  4. 3. Blood pressure-dependent changes in plasma volume, glycocalyx and platelet function during anaesthesia -Clinical and experimental studies

    Författare :Tor Damén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anaesthesia; blood pressure; hypotension; norepinephrine; haematocrit; plasma volume; atrial natriuretic peptide; glycocalyx; platelet aggregation;

    Sammanfattning : Background: Worldwide, more than 300 million surgeries are performed each year. General anaesthesia provides the surgical patient with a state of controlled loss of sensation and awareness. It is common that general anaesthesia causes hypotension. Anaesthesia-induced hypotension is associated with haemodilution and increased plasma volume (PV). LÄS MER

  5. 4. Haemostatic changes in plasma for transfusion during preparation and storage

    Författare :Anna-Maija Suontaka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :transfusion plasma; cold activation; contact system; coagulation; fibrinolysis; citrates; methylene blue; fibrinogen; stability;

    Sammanfattning : The haemostatic quality of plasma for transfusion is liable to be affected by techniques for preparation and storage. We have studied changes in the contact system, coagulation and fibrinolysis under the following conditions: blood drawn into a half-strength citrate anticoagulant solution, virus inactivation of plasma with methylene blue and red light, and plasma storage in the fluid phase. LÄS MER

  7. 5. Inhibition of the plasma contact system on endpoint immobilized heparin and human endothelium

    Författare :Javier Augusto Sánchez Saavedra; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Contact activation system; FXII; prokallikrein; antithrombin; specific AT-binding site; immobilized heparin; heparan sulphate; endothelium;

    Sammanfattning : When blood is exposed to foreign materials or injured tissue, several defense systems are activated. The contact with an artificial surface leads to activation of FXII, the first proenzyme of the plasma contact activation system, with concomitant triggering of the intrinsic coagulation and also the fibrinolytic-, kallikrein- and complement systems. LÄS MER