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Visar resultat 11 - 15 av 26 avhandlingar som matchar ovanstående sökkriterier.

1. 11. Development and Applications of Microfluidic Devices for Liver-on-a-Chip Studies

   Författare :Philip Dalsbecker; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Microfluidics; Microphysiological system; Liver-on-a-Chip; Organ-on-a-chip; Hepatocytes; Induced pluripotent stem cells; iPSC; HepG2; LX-2; on-chip differentiation; PDMS; Microfabrication; Shear stress;

   Sammanfattning : Modeling the human physiology in vitro is a challenging task, yet one of importance for the development of drugs and the study of diseases. To better address the complexities of human organs, microfluidic systems called organs-on-chips are being developed to emulate organ-specific environments for cell culture. LÄS MER

3. 12. Dynamics of Biomembranes and Rheological Properties of Living Cells

   Författare :Peter Berntsen; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cell mechanics; lipid dynamics; cell rheology; biomembranes; water dynamics; relaxations; phospholipids; glass transition;

   Sammanfattning : An ingenious assembly of biomolecules and water constitute what we call biological tissue. The presence of water in this assembly is fundamental for the physiological processes and can make the difference between life and death. LÄS MER

4. 13. Physical characterization of exosomes and other extracellular vesicles using surface-based sensing

   Författare :Deborah Rupert; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nanoparticle tracking analysis; exosomes; scattering; surface-based biosensing; optical density; cluster of differentiation 63 CD63 ; liposomes; label-free; fluorescence; surface plasmon resonance; Extracellular vesicles; specificity; antibody; lipid content; single particle; quantification; size distribution; optical waveguide microscopy;

   Sammanfattning : Extracellular vesicles (EVs) are hundred of nanometer sized particles secreted by almost all cell types. Exosomes are one type of EVs today intensively investigated due to the increased evidence suggesting that they play important roles as communicating vehicles in a broad range of physiological processes, pathological conditions and disease diagnostics. LÄS MER

5. 14. New Roads for an Ancient Enzyme : Whole-Cell Studies and New Cofactors for [FeFe] Hydrogenases

   Författare :Marco Lorenzi; Gustav Berggren; Hannah Shafaat; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; [FeFe] hydrogenases; hydrogen; catalysis; photocatalysis; spectroscopy; whole-cell; semi-artificial enzymes; Chemistry with specialization in Molecular Biomimetics; Kemi med inriktning mot molekylär biomimetik;

   Sammanfattning : [FeFe] hydrogenases rare Nature’s best H2-processing catalysts, and one of the best candidates to satisfy societal need for cheap and efficient catalyst for H2-evolution. These enzymes owe their remarkable catalytic activities to their organometallic active site, called “H-cluster”. LÄS MER

7. 15. Studies on the Role of Apoptosis in Kidney Diseases

   Författare :Linnéa Nilsson; Hjalmar Brismar; Anita Aperia; Lena Scott; Fredrik Palm; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; diabetic kidney disease; hyperglycemia; mesangial cells; microscopy; ouabain; podocytes; proximal tubule cells; RNA-seq; SGLT; Apoptos; diabetisk njursjukdom; hyperglykemi; mesangiala celler; mikroskopi; ouabain; podocyter; proximala tubuli celler; RNA-seq; SGLT; Biological Physics; Biologisk fysik;

   Sammanfattning : Apoptosis is one of the most common types of cell death. Under physiological conditions, it plays an essential role in removal of damaged and potentially harmful cells. Excessive apoptosis has however been linked to a number of diseases including proteinuric kidney disease and DKD, and is believed to enhance the disease progression. LÄS MER