Sökning: "Phase II modifications"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden Phase II modifications.

  1. 1. Toxicometabolomics and biotransformation product screening in single zebrafish embryos

    Författare :Anton Ribbenstedt; Jonathan P. Benskin; Magnus Breitholtz; Elena Gorokhova; Emma Schymanski; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Non-target; REACH; Orbitrap; single embryo; zebrafish embryo; metabolism; high throughput; hydroxylation; glucuronidation; metabolite screening; phase I; phase II; pharmaceutical; structure elucidation; conjugation; propranolol; beta blocker; Non-targeted; toxicometabolomics; Orbitrap; single embryo; 3R; metabolomics; MoA; mode of action; zebrafish embryo; carbamazepine; biotransformation; Applied Environmental Science; tillämpad miljövetenskap;

    Sammanfattning : Over the last decade environmental agencies worldwide have escalated their work to phase out animal testing for the purposes of chemical regulation. Meanwhile the number of commercially available chemicals and the requirements for hazard assessments have both increased, creating a large need for substitution of traditional in vivo assays with in vitro tests. LÄS MER

  3. 2. Development of chemical biology tools for metabolomics analysis : Phase II modifications as a link between host and microbiota co-metabolism

    Författare :Mario S. P. Correia; Daniel Globisch; Warwick Dunn; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; Chemical biology; sulfatase; Glucuronides; Phase II modifications; Microbiome; co-metabolism; method development; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Biomarker discovery is an extremely important field for early disease detection. New selective molecular markers are in high demand, as an earlier disease detection can lead to improved patient care. LÄS MER

  4. 3. Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach

    Författare :Santhilal Subhash; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Computational biology; Long noncoding RNAs; Chromatin; S-phase; Cell cycle; sperm; Epigenetics; Histone; cancer; oncogene; Tumor suppressor; DNA methylation; Histone modifications; Chromatin remodelers; lncRNAs; lincRNAs;

    Sammanfattning : One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis phase, the DNA in the cell makes a new copy to pass on genetic information to the daughter cells. LÄS MER

  5. 4. Development and Application of Proximity Assays for Proteome Analysis in Medicine

    Författare :Felipe Marques Souza de Oliveira; Masood Kamali-Moghaddam; Ulf Landegren; Mats Gullberg; Janne Lehtiö; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solid-phase proximity ligation assay; post-translational modifications; glycosylation; phosphorylation; Enzyme-linked immunosorbent assay; immunoassay and rolling circle amplification; Proximity Extension Assay; inflammation protein biomarkers; autoantibodies; autoimmune disease;

    Sammanfattning : Along with proteins, a myriad of different molecular biomarkers, such as post-translational modifications and autoantibodies, could be used in an attempt to improve disease detection and progression. In this thesis, I build on several iterations of the proximity ligation assay to develop and apply new adaptable methods to facilitate detection of proteins, autoantibodies and post-translational modifications. LÄS MER

  7. 5. Interfacial Properties of Lipid Liquid Crystalline Nanoparticles

    Författare :Pauline Vandoolaeghe; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; interaction; adsorption; surface; peptide; bilayer; cubic phase; monoolein; cubosome; lipid; liquid crystalline nanoparticles; ellipsometry; neutron reflectivity; QCM-D; SAXD;

    Sammanfattning : Lipid liquid crystalline nanoparticles are studied for their potential as biocompatible carriers for pharmaceutical, food and cosmetic applications. Their potential as delivery vehicles is due to their nanometer size, their controllable structure and physical properties and their large carrying capacity of a wide range of molecules. LÄS MER