Sökning: "Phase 1 trials"
Visar resultat 1 - 5 av 74 avhandlingar innehållade orden Phase 1 trials.
1. Patients in Clinical Cancer Trials : Understanding, Motivation and Hope
Sammanfattning : The overall aim of this thesis was to study participants' understanding of clinical cancer trials, and their motivation for participation. Of particular interest was the question of whether the patients hoped for a cure resulting from the trial. LÄS MER
2. EM Estimation in Phase Type Models
Sammanfattning : This thesis consists of four articles whose theme in common is the class of phase type distributions. In the first article an EM algorithm is presented to estimate the parameters of a phase type distribution of fixed order. Also, it is shown that the algorithm can be used to approximate other continuous distributions by phase type distributions. LÄS MER
3. Ligand-induced structural changes in HIV-1 envelope glycoprotein
Sammanfattning : The first step in HIV-1 entry is the interaction between viral envelope glycoprotein gp120 and CD4 receptor on permissive host cells. The interaction initiates a series of sequential conformational rearrangements that exposes epitopes involved in interaction with co-receptors. LÄS MER
4. A contribution to the design and analysis of phase III clinical trials
Sammanfattning : Clinical trials are an established methodology for evaluation of the effects of a new medical treatment. These trials are usually divided into several phases, namely phase I through IV. The earlier phases (I and II) are relatively small and have a more exploratory nature. LÄS MER
5. Experimental studies to overcome the recycling barriers of stainless-steel and BOF slags
Sammanfattning : This thesis presents several studies aimed at improving the recycling of steel slag. The studies are based on a first evaluation of the state-of-the-artof the recycling applications both with respect to their possibilities and limitations. LÄS MER