Sökning: "Phase 1 trials"

Visar resultat 1 - 5 av 74 avhandlingar innehållade orden Phase 1 trials.

  1. 1. Patients in Clinical Cancer Trials : Understanding, Motivation and Hope

    Författare :Tove Godskesen; Ulrik Kihlbom; Peter Nygren; Karin Nordin; Peter Strang; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; adults; clinical trials; phase 1 trials; phase 3 trials; patient information; patient education; informed consent; hope;

    Sammanfattning : The overall aim of this thesis was to study participants' understanding of clinical cancer trials, and their motivation for participation. Of particular interest was the question of whether the patients hoped for a cure resulting from the trial. LÄS MER

  3. 2. EM Estimation in Phase Type Models

    Författare :Marita Olsson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phase type distributions; coxian distribution; EM algorithm; I-divergence; density estimation; right censoring; interval censoring; standard error estimation; asymptotic theory; jackknife; relapse clinical trials; survival data; hidden Markov chain; I-divergence;

    Sammanfattning : This thesis consists of four articles whose theme in common is the class of phase type distributions. In the first article an EM algorithm is presented to estimate the parameters of a phase type distribution of fixed order. Also, it is shown that the algorithm can be used to approximate other continuous distributions by phase type distributions. LÄS MER

  4. 3. Ligand-induced structural changes in HIV-1 envelope glycoprotein

    Författare :Selina Poon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1;

    Sammanfattning : The first step in HIV-1 entry is the interaction between viral envelope glycoprotein gp120 and CD4 receptor on permissive host cells. The interaction initiates a series of sequential conformational rearrangements that exposes epitopes involved in interaction with co-receptors. LÄS MER

  5. 4. A contribution to the design and analysis of phase III clinical trials

    Författare :Vera Lisovskaja; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Clinical trials are an established methodology for evaluation of the effects of a new medical treatment. These trials are usually divided into several phases, namely phase I through IV. The earlier phases (I and II) are relatively small and have a more exploratory nature. LÄS MER

  7. 5. Experimental studies to overcome the recycling barriers of stainless-steel and BOF slags

    Författare :Mattia De Colle; Pär Jönsson; Andrey Karasev; Muxing Guo; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; stainless steel; slag; recycling; sustainability; Teknisk materialvetenskap; Materials Science and Engineering;

    Sammanfattning : This thesis presents several studies aimed at improving the recycling of steel slag. The studies are based on a first evaluation of the state-of-the-artof the recycling applications both with respect to their possibilities and limitations. LÄS MER