Sökning: "Pharmacokinetics"

Visar resultat 31 - 35 av 305 avhandlingar innehållade ordet Pharmacokinetics.

  1. 31. Metabolism of quinoline 3-carboxamide compounds, a group of synthetic immunomodulators, in various species

    Författare :Helen Tuvesson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymologi; Proteiner; enzymology; Proteins; Gastroenterologi; Gastro-enterology; pharmacokinetics; enzyme kinetics; quinoline 3-carboxamides; Keywords: Metabolism; cytochrome P450;

    Sammanfattning : Cytochrome P450 (CYP) is involved in the metabolism of the majority of clinically used drugs. We have studied the CYP mediated metabolism of quinoline 3-carboxamides, a group of synthetic immunomodulators in liver microsomal preparations from various species. LÄS MER

  3. 32. Optimization of first-line anti-tuberculosis therapy in patients co-infected with HIV

    Författare :Jesper Sundell; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tuberculosis; HIV; Pharmacokinetics; Pharmacogenetics; LC-MS MS; Individualized therapy;

    Sammanfattning : Every year over one million people die from tuberculosis. People infected with HIV are significantly more vulnerable to tuberculosis, which is the leading cause of HIV-associated death. The first-line treatment for tuberculosis consists of rifampicin, isoniazid, pyrazinamide and ethambutol. LÄS MER

  4. 33. In vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites

    Författare :Anna Lundahl; Hans Lennernäs; Dennis A Smith; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug-drug interactions; herb-drug interactions; pharmacokinetics; metabolism; CYP3A4; hydroxylation; glucuronidation; UGT enzymes; mass spectrometry; biliary excretion; urinary excretion; finasteride; PHARMACY; FARMACI;

    Sammanfattning : The general aim of this thesis was to improve the understanding of the in vivo pharmacokinetics and, in particular, the metabolism of finasteride, a 5α-reductase inhibitor used in the treatment of enlarged prostate glands and male pattern baldness. CYP3A4 has been identified as the major enzyme involved in the sequential metabolism of finasteride to ω-OH finasteride (M1) and ω-COOH finasteride (M3). LÄS MER

  5. 34. Renal dysfunction in orthopaedic surgery - with special reference to drug effects in the elderly

    Författare :Görel Nergelius; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; orthopaedics; Surgery; protein HC; IgG; albumin; pharmacokinetics; diclofenac; clearance; elderly; penicillin; isoxazolyl; tubular; glomerular; arthroplasty; exercise; traumatology; Kirurgi; ortopedi; traumatologi; Anaesthesiology; intensive care; Anestesiologi; intensivvård;

    Sammanfattning : Total hip replacement (THR) is a common procedure, generally performed in elderly persons. Previous studies indicated that the use of isoxazolyl penicillins could induce a transient post-operative renal dysfunction in these patients. LÄS MER

  7. 35. New Approaches for Levodopa Treatment in Parkinson’s Disease

    Författare :Marina Senek; Dag Nyholm; Elisabet I Nielsen; Maral Mouradian; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Pharmacokinetics; Pharmacodynamics; Population modeling; Levodopa; Carbidopa; Entacapone; Microtablets; Intestinal infusion;

    Sammanfattning : Parkinson’s disease (PD) is characterized by degeneration of dopaminergic cells, which results in dopamine depletion. Levodopa is the most effective symptomatic treatment, however, disease progression along with the unfavorable pharmacokinetics of levodopa makes the disease increasingly difficult to treat with time. LÄS MER