Sökning: "Pharmacokinetics and Drug Therapy"

Visar resultat 21 - 25 av 71 avhandlingar innehållade orden Pharmacokinetics and Drug Therapy.

1. 21. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres

   Författare :Lena E Friberg; Mats Karlsson; Alan Boddy; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI; farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Sammanfattning : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. LÄS MER

3. 22. Towards Undistorted Fluorescence for Tissue Diagnostics and Therapy Monitoring

   Författare :Haiyan Xie; Atomfysik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; upconversion; upconverting nanoparticles; fluorescence-guided-surgery; fluorescence diagnostics; photodynamic therapy; multi-spectral imaging; spectroscopy; biomedical optics; fluorescence; Fysicumarkivet A:2014:Xie;

   Sammanfattning : Fluorescence techniques for applications in tissue diagnostics and therapy monitoring were investigated and developed in the work presented in this thesis. The aim was to develop fluorescence diagnostics for the detection of malignant tumors and better delimitation of the tumor margins, using the enhanced contrast in fluorescence between tumor and surrounding healthy tissue. LÄS MER

4. 23. Optical spectroscopy in biomedicine - detection of embedded inclusions and in vivo pharmacokinetics

   Författare :Jenny Svensson; Atomfysik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; temperature; Atomic and molecular physics; Atom- och molekylärfysik; photosensitizer; photodynamic therapy; fluorescence spectroscopy; multispectral imaging;

   Sammanfattning : The main theme of this thesis is the use of fluorescence spectroscopy in biomedicine. The work presented in the thesis can be divided into three areas of applications. The first area involves the use of fluorescence to find the location of a deeply situated fluorophore within turbid media. LÄS MER

5. 24. Pharmacotherapy for Parkinson's Disease - Observations and Innovations

   Författare :Dag Nyholm; Sten-Magnus Aquilonius; Andrew Lees; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa; pharmacokinetics; infusion; drug delivery systems; electronic patient diary; Neurovetenskap; Neurology; Neurologi; Neurology; Neurologi;

   Sammanfattning : Pharmacotherapy for Parkinson’s disease (PD) is based on levodopa, the most effective dopaminergic drug. The development of motor complications constitutes the major challenge for new or refined therapies. LÄS MER

7. 25. Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies

   Författare :Elisabet I Nielsen; Lena E Friberg; Otto Cars; Mats O Karlsson; Marie Sandström; Alan Forrest; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; NONMEM; antibiotics; in vitro; time-kill curve; PK PD indices; gentamicin; aminoglycosides; newborn infants; premature infants; cystatin C; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Sammanfattning : Antibiotics are among the most commonly prescribed drugs. Although the majority of these drugs were developed several decades ago, optimal dosage (dose, dosing interval and treatment duration) have still not been well defined. LÄS MER