Sökning: "Pharmaceutical reduction"
Visar resultat 1 - 5 av 51 avhandlingar innehållade orden Pharmaceutical reduction.
1. Discovery of N-hydroxyguanidines as novel electron acceptors of xanthine oxidase : Potential new drugs for treatment of ischemia and reperfusion injury
Sammanfattning : Xanthine oxidase (EC 1.1.3.22) is one of the major enzymatic sources of oxygen-derived free radicals. LÄS MER
2. Pharmaceutical binders and their function in directly compressed tablets : Mechanistic studies on the effect of dry binders on mechanical strength, pore structure and disintegration of tablets
Sammanfattning : In this thesis, the strength-enhancing mechanisms of dry binders in direct compression were studied. The systems investigated were binary mixtures containing various compounds and binders. Among the binders used were a series of different molecular weights of polyethylene glycol. LÄS MER
3. A supercritical fluids extraction process for the production of drug loaded biodegradable microparticles
Sammanfattning : The purpose of this thesis was to develop methods suitable for the incorporation of drug substancessuch as proteins into microparticles intended for controlled release. In particular a novel techniquefor the preparation of microparticles using supercritical fluids was investigated. LÄS MER
4. Posterior capsule opacification : An experimental study in vitro and in vivo
Sammanfattning : The clinical and economic significance of posterior capsule opacification (PCO) makes it an important public health problem. A better understanding of the pathogenesis in order to reduce/prevent PCO is needed. For this purpose an experimental model in the rabbit was used and further developed in thisthesis. LÄS MER
5. Mutational analysis of melanocortin receptors 1 and 5
Sammanfattning : The melanocortin receptor family includes five subtypes, named MC1R to MC5R. Melanocortin receptors are predominantly coupled to second messenger pathway of cyclic AMP through coupling to G-protein. This study is focused on structure-function relationship of MC1R and MC5R. LÄS MER