Sökning: "Pharmaceutical Microbiology"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Pharmaceutical Microbiology.

  1. 1. UDP-sugar metabolizing pyrophosphorylases in plants : formation of precursors for essential glycosylation-reactions

    Författare :Daniel Decker; Leszek A. Kleczkowski; Henrik Vibe Schelle; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chemical library screening; Cell wall synthesis; Glycosylation; Nucleotide sugars; Oligomerization; Protein structure; Reverse chemical genetics; Sugar activation; UDP-sugar synthesis; biokemisk farmakologi; biochemical pharmacology; biokemi; Biochemistry; biology; biologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : UDP-sugar metabolizing pyrophosphorylases provide the primary mechanism for de novo synthesis of UDP-sugars, which can then be used for myriads of glycosyltranferase reactions, producing cell wall carbohydrates, sucrose, glycoproteins and glycolipids, as well as many other glycosylated compounds. The pyrophosphorylases can be divided into three families: UDP-Glc pyrophosphorylase (UGPase), UDP-sugar pyrophosphorylase (USPase) and UDP-N-acety lglucosamine pyrophosphorylase (UAGPase), which can be discriminated both by differences in accepted substrate range and amino acid sequences. LÄS MER

  3. 2. Antibiotic resistance in the environment: a contribution from metagenomic studies

    Författare :Johan Bengtsson-Palme; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; metagenomics; bioinformatics; next generation sequencing; resistance selection;

    Sammanfattning : Antibiotic resistance accounts for hundreds of thousands of deaths annually, and its projected increase has made the WHO recognize it as a major global health threat. In the last decade, evidence has mounted suggesting that the environment plays an important role in the progression of resistance. LÄS MER

  4. 3. Characterization of resistance to quinolones, sulfonamide and trimethoprim in Campylobacter jejuni as well as to macrolides in the related bacterium, Helicobacter pylori

    Författare :Amera Gibreel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmaceutical Microbiology; farmaceutisk mikrobiologi;

    Sammanfattning : Gastroenteritis caused by C. jejuni is usually a mild to moderate self-limiting disease. Treatment is recommended in some cases. In recent years, quinolones have been increasingly used to treat acute bacterial enteritis. LÄS MER

  5. 4. Characterization of a site-specific gene-transfer mechanism in bacteria

    Författare :Karin Hansson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmaceutical Microbiology; farmaceutisk mikrobiologi;

    Sammanfattning : Integrons capture and rearrange single genes borne on mobile units called cassettes using site-specific recombination. The integrons increase the variation of antibiotic resistance among bacterial plasmids and may also reorganize clustered genes in bacterial genomes. LÄS MER

  7. 5. Co-operative recombination mechanisms promoting gene clustering and lateral transfer of antibacterial drug resistance

    Författare :Masood Kamali-Moghaddam; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Tn5090 Tn402; Mu-like transposons; serine recombinases; res site; integrons; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmaceutical Microbiology; farmaceutisk mikrobiologi;

    Sammanfattning : Transposons of the Mu superfamily are widespread and have been shown to play an important role in the dissemination of antibiotic resistance among microorganisms. One of these elements, Tn5090/Tn402 is the basal vehicle of the type 1 integrons in which mobile resistance gene cassettes are inserted to form clusters and operons. LÄS MER