Sökning: "PhIP"

Hittade 5 avhandlingar innehållade ordet PhIP.

  1. 1. The effect on chromosomal stability of some dietary constituents

    Författare :Louise Durling; Per Eriksson; Jan Alexander; Uppsala universitet; []
    Nyckelord :Biology; Genotoxicity; chromosomal stability; heterocyclic amines; furan; HMF; folic acid; micronucleus test; comet assay; Biologi;

    Sammanfattning : When food is heated, a vast number of compounds are formed. Some of these are known to be toxic. Among these are furan, HMF, PhIP, IQ, and MeIQx, the subjects of this thesis. All these compounds are known or suspected carcinogens but the detailed mechanisms behind their carcinogenicity have not yet been fully examined. LÄS MER

  3. 2. Regulation of dioxin receptor function by procarcinogenic food-derived heterocyclic amines and indolocarbazoles

    Författare :Marika I Kleman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :heterocyclic aromatic amine; indolocarbazole; dioxin receptor; CYPlA;

    Sammanfattning : Cooking of protein-rich food generates procarcinogenic heterocyclic aromatic amines(HCA) in amounts that range in the part per billion levels. The capacity of the two most prevalent HCA, PhIP and MelQx, to induce genetic alterations in vivo was determined using a short-term liver carcinogenesis model (RH-model) in rat. LÄS MER

  4. 3. Capillary electroseparations with mass spectrometric detection Nanoparticle-based continuous full filling and applications for complex sample matrices

    Författare :Peter Viberg; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytisk kemi; Analytical chemistry; phthalates; continuous full filling; heterocyclic aromatic amines; pseudostationary phase; capillary electrophoresis; electrokinetic chromatography; capillary electrochromatography; nanoelectrospray; mass spectrometry;

    Sammanfattning : One of the major challenges in analytical chemistry is to find techniques and methods for determinations of low abundance compounds in complex sample matrices. This thesis describes the development of new miniaturised analytical techniques comprising capillary electroseparation combined with mass spectrometric detection. LÄS MER

  5. 4. Modifying Cooking Practices to Reduce the Formation of Heterocyclic Amines

    Författare :Elna Hallgard; Avdelningen för livsmedel och läkemedel; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Livsmedelsteknik; Food and drink technology; cancer; frying; mutagens; beefburger; chicken; heterocyclic amines; cooking;

    Sammanfattning : Commonly cooked meat dishes contain heterocyclic amines (HAs) at ng/g levels. HAs are animal carcinogens, form DNA adducts in human tissues, and have been associated with increased risk of cancer in epidemiological studies, and it is thus recommended that human intake be decreased. LÄS MER

  7. 5. Impact of Bifidobacterium longum and Lactobacillus acidophilus on the intestinal microflora and bioavailability of some food mutagens

    Författare :Kerstin Orrhage; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The gastrointestinal microflora is a complex ecological system, normally characterised by a flexible equilibrium. The most important role of the microflora, from the point of view of the host, is probably to act in colonisation resistance against exogenous, potentially pathogenic, microorganisms. LÄS MER