Sökning: "PfEMP1"

Visar resultat 1 - 5 av 23 avhandlingar innehållade ordet PfEMP1.

1. 1. Surface antigens in Plasmodium falciparum malaria : PfEMP1 and SURFIN4.2

   Författare :Maria del Pilar Quintana Varon; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Plasmodium falciparum malaria is an infectious disease that on despite of the ongoing eradication efforts is still endemic in more than 100 countries, sometimes causing severe disease that leads to the death of around half a million people per year. Malaria pathology is tightly associated with the parasite cycle inside the human red blood cells (RBCs). LÄS MER

3. 2. Virulence in Plasmodium falciparum malaria : mechanisms of PfEMP1-mediated rosetting

   Författare :Davide Angeletti; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Malaria is one of the most important infectious diseases in the world and the Plasmodium falciparum parasite is the causative agent of most of the severe cases. The pathogenesis of the disease is complex but sequestration and hence microvascular obstruction is associated with virulence of the parasite. LÄS MER

4. 3. Antigenic variation and virulence in Plasmodium falciparum malaria : studies on the surface protein PfEMP1

   Författare :Karin Blomqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Approximately 40% of the world’s population is at risk of contracting malaria, a disease caused by the intracellular protozoan Plasmodium. The species Plasmodium falciparum is responsible for the majority of severe morbidity and mortality. LÄS MER

5. 4. Immunoglobulins in the adhesion of Plasmodium falciparum-infected erythrocytes in malaria

   Författare :Carin Scholander; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Plasmodium falciparum; rosetting; cytoodhesion; immunoglobulins; serum proteins; fibrillar structures; malarial anaemia; placental malaria; PfEMP1;

   Sammanfattning : Characterisation of the delicate cell-to-cell interactions involved in the binding of Plasmodium falciparum- infected erythrocytes to host cells is central for the understanding of the development of severe malaria. Infected erythrocytes adhere in the deep vasculature of several organs, sequestration, leading to cerebral malaria, pulmonary oedema or renal failure. LÄS MER

7. 5. Variable surface molecules of the plasmodium falciparum infected erythrocyte and merozoite

   Författare :Malin Haeggström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :P.falciparum; infected erythrocytes; transport; Maurer s clefts; antigenic variation; PfEMP1; RIFIN; SURFIN; merozoites; subgroups;

   Sammanfattning : As Plasmodium falciparum parasites matures within the infected erythrocyte (IE) it produces a number of various proteins, which are transported out to the cell surface where they are exposed to the host immune system. To avoid recognition and elimination by the liver and spleen these proteins can undergo antigenic variation, a phenomenon where the parasites switch from expressing one variant to' another, both belonging to the same gene-family. LÄS MER