Sökning: "Peter Nygren"
Visar resultat 11 - 15 av 21 avhandlingar innehållade orden Peter Nygren.
11. Proteomics informed investigation of human hepatocytes and liver tissue
Sammanfattning : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. LÄS MER
12. Internet-based Psychosocial Support : Design, Effects and User Experience in the Cancer Setting
Sammanfattning : Background and Aim Being diagnosed with cancer is often described as a major loss of control leading to severe psychological distress and symptoms of anxiety and depression can continue to affect the individual in the long term. The cancer and its treatment may influence all dimensions of health, thus the psychosocial support provided needs to be multifaceted and easy accessed. LÄS MER
13. Quality of life, Coping and need for Support during the ALS disease trajectory
Sammanfattning : The overall aim of this thesis was to investigate quality of life, coping and emotional distress (i.e. anxiety and depression) among newly diagnosed ALS patients. An additional aim was also to investigate relatives’ experiences of the care for the patient and the support they received for themselves during the disease progression. LÄS MER
14. New preclinical strategies for characterization and development of anticancer drugs
Sammanfattning : Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target driven drug development the last decades, but the development of effective cancer drugs has been hampered by the lack of predictive preclinical models. 3-D cultures, considered to more accurately reflect solid tumors in vivo, have been proposed as one way to increase the predictability of clinical efficacy in cancer drug discovery and development. LÄS MER
15. Preclinical Characterization in vivo and in vitro of Novel Agents for Cancer Chemotherapy : Studies on Benomyl, Carbendazim, Cryptolepine and Acriflavine
Sammanfattning : Preclinical methods for the identification and characterization of molecules for development into new cancer drugs were investigated. Based on repurposing, i.e. LÄS MER