Sökning: "Peter J. Svensson"

Hittade 4 avhandlingar innehållade orden Peter J. Svensson.

  1. 1. Systematic Modular Approaches to Reveal DNA Damage Responses in Mammalian Cells

    Författare :J. Peter Svensson; Ingela Turesson; Jean Bourhis; Uppsala universitet; []
    Nyckelord :Molecular biology; gene expression profiling; DNA damage; network; cancer; ionizing radiation; cisplatin; Molekylärbiologi;

    Sammanfattning : Cancer therapy operates by inflicting damage in malignant cells. The most lethal target is the genomic DNA. As a single double strand DNA break has the potential to kill the cell, mechanisms have evolved to detect and block propagation of the damage. LÄS MER

  3. 2. Anticoagulation treatment in patients with a mechanical heart valve

    Författare :Bartosz Grzymala-Lubanski; Anders Själander; Peter J. Svensson; David Bergqvist; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mechanical heart valve; anticoagulation; warfarin; Time in Therapeutic Range TTR ; INR variability;

    Sammanfattning : BackgroundEvery year about 2,500 patients in Sweden undergo surgery for heart valve disease, primarily in the aortic valve.  In contrast to the mitral valve, which can be repaired in 70% of the cases, the aortic valve is normally replaced by a mechanical or biological prosthesis. LÄS MER

  4. 3. Stroke prevention in atrial fibrillation

    Författare :Sara Själander; Peter J. Svensson; Bo Carlberg; Håkan Walfridsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atrial fibrillation; stroke; oral anticoagulation; aspirin; haemorrhage; electrical cardioversion; pulmonary vein isolation; Cardiology; kardiologi;

    Sammanfattning : Background: The Framingham Study from 1991 showed a clear correlation between atrial fibrillation (AF) and ischemic stroke, where patients with AF had an almost fivefold increase in risk of stroke compared with patients without AF. Since then, several trials have evaluated different antithrombotic treatments to reduce the risk of stroke in patients with AF. LÄS MER

  5. 4. Oral anticoagulation and stroke risk

    Författare :Vilhelm Sjögren; Anders Själander; Per Wester; Peter J Svensson; Mia von Euler; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Stroke; warfarin; atrial fibrillation; dabigatran; rivaroxaban; apixaban; low-molecular-weight heparin; bridging;

    Sammanfattning : Background: The risk of ischaemic stroke in patients with atrial fibrillation (AF) and mechanical heart valve (MHV) prostheses can be reduced by oral anticoagulation (OAC), which increases the risk of serious bleeding. The aims of this thesis were [1] to find out how effective and safe warfarin is where treatment quality is high, i.e. LÄS MER