Sökning: "Peter Brzezinski"

Visar resultat 6 - 10 av 22 avhandlingar innehållade orden Peter Brzezinski.

1. 6. Adaptive Responses by Transcriptional Regulators to small molecules in Prokaryotes : Structural studies of two bacterial one-component signal transduction systems DntR and HpNikR

   Författare :Cyril Dian; Peter Brzezinski; Séan McSweeney; Elisabeth Sauer-Eriksson; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transcription regulator; bacterial biosensor; LysR family; Inducer-binding; nickel-sensing; NikR; signal transduction system; Helicobacter pylori; Biochemistry; Biokemi; biokemi; Biochemistry;

   Sammanfattning : Prokaryotes are continually exposed to variations in their environment. Survival in unstable milieu requires a wide range of transcriptional regulators (TRs) that respond to specific environmental and cellular signals by modulating gene expression and provide an appropriate physiological response to external stimuli. LÄS MER

3. 7. Structural elements involved in protein-mediated proton transfer : Implications from studies of cytochrome c oxidase

   Författare :Ann-Louise Johansson; Martin Högbom; Peter Brzezinski; Bertrand García-Moreno; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; proton transfer; Biochemistry; biokemi;

   Sammanfattning : Proton transfer is one of the most common reactions in biological systems. During energy conversion inside a cell, proton transfer is crucial to maintain an electrochemical proton gradient across the cell membrane. This gradient is in turn used to e.g. LÄS MER

4. 8. Experimental studies of proton translocation reactions in biological systems : Electrogenic events in heme-copper oxidases

   Författare :Håkan Lepp; Peter Brzezinski; Thomas Nilsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; heme-copper oxidase; cytochrome c oxidase; nitric oxide reductase; cbb3-type oxidase; proton pumping; uncoupling; charge-transfer; electrogenic event; flow-flash; Biophysics; Biofysik; Biophysics; biofysik;

   Sammanfattning : Terminal heme-copper oxidases (HCuOs) are transmembrane proteins that catalyze the final step in the respiratory chain - the reduction of O2 to H2O, coupled to energy conservation by generation of an electrochemical proton gradient. The most extensively investigated of the HCuOs are the aa3-type oxidases, to which cytochrome c oxidase (CytcO) belongs, which uses energy released in the O2-reduction for proton pumping. LÄS MER

5. 9. In search of a biosensor for DNT detection : Studies of inducer response and specificity of DntR

   Författare :Rosa Lönneborg; Peter Brzezinski; Ray Dixon; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DntR; transcriptional regulation; gfp; nitro-aromatic compounds; LysR family; LTTR; TNT; DNT; FACS; directed evolution; random mutagenesis; recombination; structure determination; biokemi; Biochemistry;

   Sammanfattning : The primary aim of the work presented in this thesis was to change the inducer specificity of the DntR protein in order to improve the response to DNT. The long-term goal is to use this protein in a biosensor for DNT, a signature compound for detection of the explosive TNT. LÄS MER

7. 10. Role of respiratory supercomplexes : Electronic connection between complexes III and IV

   Författare :Agnes Moe; Peter Brzezinski; James A. Letts; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; electron transfer; cytochrome c oxidase; cytochrome bc1; respiratory supercomplex; bioenergetics; membrane protein; biokemi; Biochemistry;

   Sammanfattning : In the final step of cellular respiration, electrons are transferred through the respiratory chain to reduce molecular oxygen to water. The energy released in this chain is used to maintain a proton electrochemical gradient across the cell membrane, which is used, for example, by the ATP synthase to produce ATP. LÄS MER