Sökning: "Peroxiredoxins"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Peroxiredoxins.

  1. 1. Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae

    Författare :Veronica Andersson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; aging; aggregates; proteostasis; proteasome; disaggregation; peroxiredoxins; asymmetric inheritance; S. cerevisiae;

    Sammanfattning : Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of any part of this proteostasis network may have severe consequences for cellular fitness and longevity. LÄS MER

  3. 2. On chaperone co-operation in temporal and spatial protein quality control

    Författare :Rebecca Andersson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular chaperones; Heat shock proteins; Hsp70 chaperones; Proteostasis; Ageing; Asymmetric damage segregation; Peroxiredoxins; Spatial protein quality control;

    Sammanfattning : In order for a protein to be able to function correctly it needs to adopt its proper fold. Because of this, protein quality control (PQC) is vital at every level of cellular function. The central protein in PQC networks across all kingdoms of life are the Hsp70 molecular chaperones. LÄS MER

  4. 3. Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin

    Författare :Sarah Hanzén; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging; Caloric restriction; Oxidative stress; Peroxiredoxins; Proteostasis; Protein aggregates; Ubiquitin-proteasome system;

    Sammanfattning : Aging is characterized by a progressive decline in physiological functions that limits biological processes, increases the risk of disease, and ultimately leads to death. At the cellular level, aging is associated with accumulation of damaged components, including proteins, indicating that protein homeostasis (or proteostasis) fails to maintain the integrity and functionality of the proteome as cells age. LÄS MER

  5. 4. Peroxiredoxins in Redox Signaling and Aging

    Författare :Friederike Roger; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Aging; Peroxiredoxin; Redox Signaling; Caloric restriction; light sensing;

    Sammanfattning : Peroxiredoxins have emerged as conserved modulators of the rate of aging in yeast and multicellular organisms and play a role in lifespan extension through the anti-aging intervention caloric restriction. Yet, it is not clear through what mechanism peroxiredoxins extend lifespan. LÄS MER

  7. 5. Illumination in single cell optical microscopy studies - friend and foe

    Författare :Kristofer Bodvard; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; yeast; transcription factors; signalling; fluorescence microscopy; Saccharomyces cerevisiae; light-induced stress; phototoxicity; single cell imaging;

    Sammanfattning : This thesis focuses on how to use light as a biological stress factor in optical microscopy experiments and simultaneously use the illumination to image the spatial and temporal protein dynamics in single yeast cells. The stress responses to environmental changes other than light have been extensively investigated in budding yeast, Saccharomyces cerevisiae, often using techniques based on population averages. LÄS MER