Sökning: "Pernilla Wittung"

Hittade 5 avhandlingar innehållade orden Pernilla Wittung.

1. 1. Functional interactions of nucleic acids : in simple DNA analogs and recombinase intermediates

   Författare :Pernilla Wittung; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : .... LÄS MER

3. 2. Intelligent Nucleic Acid Interactions with Peptide Nucleic Acid (PNA) and Recombination Enzyme RecA

   Författare :Pernilla Wittung; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fluorescence; RecA; homologous recombination; circular dichroism; DNA analogs; -anti-BPDE; spectroscopy; PNA; DNA-protein interactions;

   Sammanfattning : The work presented in this thesis focuses on interactions between nucleic-acids in biological systems, particularly interactions of the promising drug-candidate peptide nucleic acid (PNA), and on protein-DNA intermediates during recombination. Several experimental techniques, mainly circular dichroism and fluorescence spectroscopy, have been used to characterize the interactions of interest. LÄS MER

4. 3. Effects of Macromolecular Crowding on Protein Folding : - in-vitro equilibrium and kinetic studies on selected model systems

   Författare :Alexander Christiansen; Pernilla Wittung-Stafshede; Thomas Kiefhaber; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein Folding; macromolecular crowding; excluded volume; spectroscopy; stopped-flow; biokemi; Biochemistry;

   Sammanfattning : Protein folding is the process during which an extended and unstructured polypeptide converts to its compact folded structure that is most often the functional state. The process has been characterized extensively in dilute buffer in-vitro during the last decades but the actual biological place for this process is the inside of living cells. LÄS MER

5. 4. Copper-transporting proteins and their interactions with platinum-based anticancer substances

   Författare :Maria Espling; Pernilla Wittung-Stafshede; Oleg Dmitriev; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cisplatin; Atox1; copper transport; anticancer drug; resistance; platinum; spectroscopy.; biologisk kemi; biological chemistry;

   Sammanfattning :   Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. LÄS MER

7. 5. Human copper ion transfer : from metal chaperone to target transporter domain

   Författare :Moritz Sebastian Niemiec; Pernilla Wittung-Stafshede; Nigel Robinson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; copper homeostasis; copper chaperone; Atox1; ATP7B; Wilson disease protein; metal transport; size exclusion chromatography; thermodynamics; isothermal calorimetry;

   Sammanfattning : Many processes in living systems occur through transient interactions among proteins. Those interactions are often weak and are driven by small changes in free energy. LÄS MER