Sökning: "Perilipin 1"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Perilipin 1.

  1. 1. Perilipin expression in the islets of Langerhans and Surface expression in the baculovirus/insect cell system

    Författare :Jörgen Borg; Molekylär endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biology; Biologi; lipotoxicity; beta-cell; perilipin; amino-terminal anchor; Baculovirus; surface display;

    Sammanfattning : Surface display in insect cells: Systems available for surface display that utilize bacterial phages are insufficient for displaying a number of eukaryotic proteins. By instead presenting proteins on the surface of eukaryotic cells or virus, some of these problems might be overcome. LÄS MER

  3. 2. Regulation of glycerol efflux in adipocytes. Structural and functional studies of the glycerol channel aquaporin 7

    Författare :Sofia de Mare; Medicinsk strukturbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glycerol : metabolism; Lipolysis; X-ray Crystallography; Perilipin 1; Aquaglyceroporin; Aquaporin 7; Adipocytes metabolism; Glycerol : metabolism; adipocyte metabolism; X-ray crystallography; Aquaglyceroporin; Aquaporin 7; Perilipin 1; Lipolysis;

    Sammanfattning : Glycerol levels in adipocytes depend on the lipolysis, the hydrolysis of triglycerides into glycerol and free fatty acids, and the efflux of glycerol across the plasma membrane through glycerol channels. The aims of this work were to investigate how glycerol levels are regulated on a molecular level by PLIN1, a major lipid droplet-associated protein and a key regulator of the lipolysis by scaffolding for lipolytic proteins on the lipid droplet. LÄS MER

  4. 3. Intracellular lipids and inflammatory activity in macrophage foam cells

    Författare :Jenny Persson; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; lipid droplet; cytokine; inflammation; adipophilin; perilipin; atherosclerosis; Macrophage; foam cell;

    Sammanfattning : Cardiovascular disease (CVD) is characterized by lipid accumulation and inflammation in arteries. The disease starts early in life with migration of monocytes into the arterial wall where they engulf entrapped lipoproteins and become macrophage foam cell. LÄS MER

  5. 4. Lipid Metabolism and Insulin Signalling in Adipocytes : enhanced autophagy in type 2 diabetes

    Författare :Anita Öst; Peter Strålfors; Johanna Gustavsson Dahlberg; Anna Krook; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Energy storage in the adipose tissue, to an extent leading to obesity, is associated with local as well assystemic insulin resistance. When insulin-producing beta-cells in the pancreas gradually fail tocompensate, plasma levels of glucose rise and overt type 2 diabetes is diagnosed. LÄS MER

  7. 5. Dietary effects on gene regulation and function in human adipose tissue in obesity

    Författare :Elisabet Nordström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity is an excess of body fat that develops from both genetic and environmental factors, leading to a disturbed balance between energy intake and energy expenditure. It is closely associated with insulin resistance, type 2 diabetes, hyperlipidemia and atherosclerosis. Its increasing prevalence has reached epidemic proportions worldwide. LÄS MER