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Visar resultat 1 - 5 av 20 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets

   Författare :Joey Lau; Per-Ola Carlsson; Leif Jansson; Carina Carlsson; Caroline Kampf; Annika Tibell; Uppsala universitet; []
   Nyckelord :Cell biology; Type 1 diabetes; pancreatic islets; human islets; islet transplantation; vascular engraftment; revascularization; implantation-site; microenvironment; vascular density; insulin release; pro insulin biosynthesis; glucose oxidation; Cellbiologi;

   Sammanfattning : Transplanting pancreatic islets into the liver through the portal vein is currently the most common procedure in clinical islet transplantations for treating patients with brittle type 1 diabetes. However, most islet grafts fail within a 5-year period necessitating retransplantation. LÄS MER

3. 2. Microcirculation in native and transplanted rodent pancreatic islets with special reference to the influence of diabetes mellitus

   Författare :Per-Ola Carlsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; islet microcirculation; microspheres; micropuncture technique; islet blood flow; islet capillary pressure; oxygen tension; transplanted islets; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : The aim of the present work was to characterize the islet microcirculation in animal models of type 1 and type 2 diabetes, as well as in islets transplanted to diabetic or normoglycemic recipients. For this purpose, a microsphere technique was evaluated and applied for measurements of islet blood flow in mice. LÄS MER

4. 3. Influence of Islet-derived Factors in Islet Microcirculation and Endocrine Function

   Författare :Carl Johan Drott; Per-Ola Carlsson; Leif Jansson; Albert Salehi; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes mellitus; pancreas; blood flow; islet vascularity; islet-derived; TSP-1; ghrelin; CART; irisin; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Diabetes mellitus is a disorder with complex pathology and is frequently associated with vascular complications. In the islet micro milieu locally generated factors may affect both the physiology and the morphology of the tissue. LÄS MER

5. 4. Pharmaceutical Protection of Beta-Cells in Diabetes : Using Tyrosine Kinase Inhibition and NOX4 Inhibitors

   Författare :Andris Elksnis; Per-Ola Carlsson; Nils Welsh; Sergiu-Bogdan Catrina; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes mellitus; Tyrosine kinase inhibitors; Imatinib; AMPK; Oxidative stress; NADPH-oxidase; NOX; NOX4; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Diabetes mellitus is a complex and heterogenous disease, with loss of beta-cell function and mass being a characteristic of not only type 1 diabetes (T1D), but also type 2 diabetes (T2D). In T1D, inappropriate inflammatory signaling is thought to participate in the autoimmune suppression and destruction of beta-cells. LÄS MER

7. 5. Engraftment of Pancreatic Islets in Alternative Transplantation Sites and the Feasibility of in vivo Monitoring of Native and Transplanted Beta-Cell Mass

   Författare :Daniel Espes; Per-Ola Carlsson; Joey Lau; Mia Phillipson; Eelco de Koning; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Islet transplantation; Alternative implantation sites; Exendin-4; Positron Emission Tomography; 5-hydroxy tryptophan; Beta-cell mass; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Islet transplantation is a possible curative treatment for type 1 diabetes (T1D). Currently the liver dominates as implantation site, despite the many challenges encountered at this site.Acute hypoxia in islets transplanted to muscle and omentum, two possible alternative sites, was prevailing. LÄS MER