Sökning: "Per Strand"

Visar resultat 26 - 28 av 28 avhandlingar innehållade orden Per Strand.

1. 26. Interstrand Crosslinks - Induction and repair

   Författare :Daniel Vare; Dag Jenssen; Klaus Erixon; Fredrik Johansson; Marcel Tijsterman; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ICL; DNA repair; interstrand crosslink; psoralen; molekylärgenetik; Molecular Genetics;

   Sammanfattning : DNA crosslinking agents exhibit a variety of DNA lesions, such as monoadducts, DNA-DNA interstrand or intrastrand crosslinks or DNA-protein crosslinks. Agents that produce interstrand crosslinks (ICLs) exist naturally and are widely used in chemotherapy. Therefore, it is important to understand how the lesions induced by these agents are repaired. LÄS MER

3. 27. Novel methods to study genomic fragility and structural variation

   Författare :Reza Mirzazadeh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : DNA double-strand breaks (DSBs) are major DNA lesions that when repaired unfaithfully can give rise to loss of genetic information, chromosomal rearrangements such as insertions/deletions (indels) and copy number alterations (CNAs), which in turn lead to genomic instability that is characteristic of almost all cancer types. In this context, it is thought that genomic instability has critical roles in cancer initiation, progression and intra-tumor heterogeneity (ITH). LÄS MER

4. 28. DNA fragility in the context of neural stem cell fate : a multi-method integrative exploration of genome dynamics

   Författare :Roberto Ballarino; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Recent advances in mapping the complex genetic architecture underlying various debilitating brain disorders have enabled identification of several genetic risk variants. However, these risk variants only explain part of the heritability and vulnerability to these disorders in early development. LÄS MER