Sökning: "Peptide receptor radionuclide therapy PRRT ."

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Peptide receptor radionuclide therapy PRRT ..

  1. 1. Peptide Receptor Radionuclide Therapy in Neuroendocrine Neoplasms : Aspects of tumour characteristics, receptor recycling and peptide mass

    Författare :Ulrika Jahn; Anders Sundin; Mark Lubberink; Ulrike Garske-Román; Mona-Elisabeth Rootwelt-Revheim; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroendocrine tumors; Peptide receptor radionuclide therapy PRRT ; Peptide; Small-Intestinal; Pancreatic; Dosimetry; Somatostatin receptor;

    Sammanfattning : Neuroendocrine neoplasm (NEN) can arise in any part of the body, but most commonly in the lungs, bronchi, and the gastrointestinal tract including the pancreas. They combine neuroendocrine and tissue-of-origin-specific characteristics; explaining different symptoms depending on the organ of origin. LÄS MER

  3. 2. Strategies for optimisation of 177Lu-octreotate therapy – exploring local administration and combination therapy regimens

    Författare :Viktor Sandblom; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peptide receptor radionuclide therapy; PRRT; 177Lu-octreotate; Neuroendocrine tumours; Optimisation; Local administration; Combination therapy;

    Sammanfattning : Neuroendocrine tumours (NETs) are a group of heterogeneous tumour types that originate in hormone-producing organs. Patients with NETs are often diagnosed after the primary tumour has metastasised. LÄS MER

  4. 3. Theranostics in Neuroendocrine Tumors : Somatostatin Receptor Imaging and Therapy

    Författare :Ezgi Ilan; Mark Lubberink; Peter Bernhardt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 177Lu-DOTATATE; 68Ga-DOTATATE; 68Ga-DOTATOC; PRRT; Theranostics; PET CT; SPECT CT; Neuroendocrine tumors; Somatostatin receptors; Medicinsk radiofysik; Medical Radiophysics;

    Sammanfattning : Neuroendocrine tumors (NETs) are characterized by cellular overexpression of somatostatin receptors (SSTR), which allows for the use of radiolabeled somatostatin analogs (SSA) for both imaging and therapy. Because NETs often are diagnosed at a metastatic stage, curative surgery is not possible. LÄS MER

  5. 4. lmprovement of 177Lu-octreotate treatment of small-intestine neuroendocrine tumors by hyperfractionation

    Författare :Mikael Elvborn; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peptide receptor radionuclide therapy; PRRT; somatostatin receptor; SSTR; apoptosis; gene expression; epigenetic effects;

    Sammanfattning : Neuroendocrine tumor incidence is steadily rising, and the late diagnosis often results in metastatic disease and current treatments mostly prolong life and in-crease quality of life without increasing cure rate. 177Lu-octreotate was recently approved for treatment of neuroendocrine tumors, but the dosage scheme should be optimized. LÄS MER

  7. 5. Computational patient models for simulation of dynamic gamma-camera imaging : Application to renography and peptide receptor radionuclide therapy

    Författare :Gustav Brolin; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nuclear medicine; Gamma camera; Renography; Radionuclide therapy; Internal dosimetry; Pharmacokinetics;

    Sammanfattning : Many nuclear medicine investigations rely on gamma-camera imaging to study and quantify the distribution of radiopharmaceuticals or radionuclides in the patient as a function of time. This is typically used for diagnostic studies of physiological functions or for calculation of absorbed doses following radionuclide therapy. LÄS MER