Sökning: "Peptide inhibitor conjugate"
Hittade 5 avhandlingar innehållade orden Peptide inhibitor conjugate.
1. Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule : Peptide Conjugates as Protein Actors
Sammanfattning : This thesis describes different aspects of protein interactions. Initially the function of peptides and their conjugates with small molecule inhibitors on the surface of Human Carbonic Anhydrase isoenzyme II (HCAII) is evaluated. LÄS MER
2. Development of Peptide Binders : Applied to Human CRP, Carbonic Anhydrase (II, IX) and Lysine Demethylase 1
Sammanfattning : In this thesis, a polypeptide binder concept is illustrated. By conjugation to a set of sixteen polypeptides, a small binding molecule can evolve into a polypeptide binder with increased affinity and selectivity. LÄS MER
Sammanfattning : The overall theme of this thesis is a step by step approach for the design and characterization of conjugated protease inhibitors. This involves both a new assay method for protease activity and protease inhibition (paper I), a study of the stoichiometry for protease inhibitor interaction (paper II), design of inhibitory peptides (paper IV) and the construction of inhibitor conjugates (paper III & IV). LÄS MER
Sammanfattning : This thesis describes the design, synthesis and characterization of synthetic receptor molecules for the recognition and binding of proteins with applications in bioseparation and biosensing. A 42-residue polypeptide, designed to fold into a helix-loop-helix motif and dimerize in solution to form a four-helix bundle, was used as the scaffold. LÄS MER
5. Development of 18F- and 68Ga-Labelled Tracers : Design Perspectives and the Search for Faster Synthesis
Sammanfattning : This thesis deals with the design of 18F- and 68Ga-labelled positron emission tomography (PET) tracers and the development of technologies that enable faster and simpler preparation with high specific radioactivity. Techniques like microwave heating and reducing the concentrations of the precursor were investigated with this perspective. LÄS MER