Sökning: "Peptide hydrogel"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Peptide hydrogel.
1. Microgel Interactions with Peptides and Proteins : Consequence of Peptide and Microgel Properties
Sammanfattning : Microgels are lightly cross-linked hydrogel particles in the sub-micrometer to micrometer size range with a capacity to drastically change their volume in response to changes in the external environment. Microgels have an ability to bind and store substances such as biomacromolecular drugs, notably proteins and peptides, and release them upon stimuli, making them potential candidates as drug delivery vehicles and functional biomaterials. LÄS MER
2. On the colloidal and molecular aspects of peptide self-assembly
Sammanfattning : Peptide self-assembly is a spontaneous process, ubiquitous in nature for the creation of highly ordered and complex biological structures, making it a sought after technique in the development of novel biocompatible materials. The process is also strongly associated with various neurodegenerative diseases in the formation of amyloid plaques in diseases such as Alzheimer’s and Parkinson’s, where fully functioning proteins aggregate are reassembled into nonfunctional fibrillar aggregates that eventually lead to cell death. LÄS MER
3. Antibacterial elastomeric materials for biomedical applications
Sammanfattning : An ageing population in combination with scientific and clinical advancements have led to a steady increase in the use of medical devices. Elastomeric biomaterials – materials displaying rubber-like mechanics – have found widespread applicability in the production of both short- and long-term medical devices. LÄS MER
4. Modular Enzyme-Responsive Polysaccharide-Based Hydrogels for Biofabrication
Sammanfattning : Engineered human tissue and disease models can decrease the cost and time of developing new drugs and treatments, facilitate personalized medicine, and eliminate the need for animal models that poorly represent the human body and are ethically problematic. However, the current conventional cell expansion methods using 2D culture flasks cannot enable the development of such complex multi-cellular 3D models. LÄS MER
5. Development of biosynthetic conduits for peripheral nerve repair
Sammanfattning : Peripheral nerve injuries are often associated with significant loss of nervous tissue leading to poor restoration of function following repair of injured nerves. Although the injury gap could be bridged by autologous nerve graft, the limited access to donor material and additional morbidity such as loss of sensation and scarring have prompted a search for biosynthetic nerve transplants. LÄS MER
