Sökning: "PepFect"

Visar resultat 6 - 8 av 8 avhandlingar innehållade ordet PepFect.

  1. 6. Cell-penetrating peptides : an uptake mechanism & a new endosomolytic peptide

    Författare :Henrik Helmfors; Ülo Langel; Andreas Barth; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Peptide-based drugs have slowly begun migrating from laboratories into pharmacies and now there are several on the market. However, currently only one gene based therapy that is relies on a viral delivery vector has been approved. LÄS MER

  3. 7. Optimization of the formulation and design of oligonucleotide-based pharmaceuticals for the purpose of gene therapy

    Författare :Eman M Zaghloul; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oligonucleotides (ONs) are short sequences of nucleic acids which may be used in a therapeutic context to modulate gene expression. According to their target, ONs can be classified into two main classes: antisense ONs which target mRNA and antigene ONs that target chromosomal DNA. LÄS MER

  4. 8. CELL PENETRATING PEPTIDES : CHEMICAL MODIFICATION AND FORMULATION DEVELOPMENT

    Författare :Kariem Ezzat; Ülo Langel; Astrid Gräslund; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Cell penetrating peptides (CPPs) have been extensively studied and exploited as drug delivery vectors for a wide variety of therapeu-tic cargos. However, several issues remain to be addressed regarding the enhancement of their efficiency and stability. LÄS MER