Sökning: "Pentoxifylline"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet Pentoxifylline.

  1. 1. Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites

    Författare :Marie V Magnusson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; Pentoxifylline; metabolites; pharmacodynamics;

    Sammanfattning : Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). LÄS MER

  3. 2. Intrinsic radiosensitivity and molecular targets for tumour radiosensitization of head and neck cancer. With special reference to chromosomal instability and pentoxifylline

    Författare :Anna Danielsson; Göteborgs universitet; []
    Nyckelord :radiosensitivity; clonogenic survival; radio-sensitizer; chromosomal instability; cell cycle regulation; G2 checkpoint; pentoxifylline;

    Sammanfattning : .... LÄS MER

  4. 3. Radiotherapy in Early Breast Cancer

    Författare :Fredrika Killander; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pentoxifylline; cyclophosphamide; tamoxifen; side effects; randomised trial; Breast cancer; radiotherapy;

    Sammanfattning : Radiotherapy (RT) after mastectomy has been part of the treatment for early breast cancer since the 1940s. The treatment reduces the risk of loco-regional recurrences, but implies risk of late side effects that can begin decades after RT. LÄS MER

  5. 4. High Affinity Synthetic Molecular Binders for Proteins : Design, Synthesis and Evaluation

    Författare :Xiaojiao Sun; Lars Baltzer; Thomas Norberg; Ulf Nilsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polypeptide; conjugates; D-dimer; myeloperoxidase; chitinase;

    Sammanfattning : This thesis describes the design and synthesis of small molecule derivatives and their polypeptide conjugates as high affinity binders for proteins: the D-dimer protein (D-dimer), a biomarker for diagnosis of thromboembolic diseases; human myeloperoxidase (MPO), a biomarker for cardiovascular diseases; and chitinases, potential targets for asthma therapy. The interactions between the synthetic binder molecules and those proteins were evaluated by surface plasmon resonance (SPR) biosensor analysis and fluorescence spectroscopy. LÄS MER

  7. 5. Insights into the role of spinal mTOR in the modulation of inflammation and nociception

    Författare :Ebba Gregory; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pain, especially chronic pain, is a major clinical problem. Pain therapy has proven to be complicated and the results are often unsatisfactory. Despite many years of research, the number of available pain therapeutics remains relatively small. LÄS MER