Sökning: "Parkinson s disease dementia"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Parkinson s disease dementia.

1. 1. Cardiovascular disease in dementia

   Författare :Pavla Cermakova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The objective of this thesis was to characterize the burden of cardiovascular diseases in patients with dementia, their treatment and association with survival. Further, we aimed to explore whether cardiac structure in young adults can affect the aging brain. LÄS MER

3. 2. Role of Neuroinflammation in Parkinson's Disease and Related Disorders

   Författare :Edoardo Brandi; Neural plasticitet och reparation; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha synuclein; Preformed fibrils; Microglia; Astrocyte; Neuroinflammation; Lipopolysaccharides; Parkinson Disease; Lewy Body Dementia; Multiple system atrophy; Synucleinopathies;

   Sammanfattning : Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates, progressive neurodegeneration, and neuroinflammation. Alpha-synuclein (a-syn) is the principal component of intracellular aggregates and can be modified by several mutations and post-translational modifications (PTMs), which can alter the protein structure affecting its aggregation, toxicity, and ability to spread. LÄS MER

4. 3. Clusterin in brain and cerebrospinal fluidin Alzheimer s disease

   Författare :Anna-Maria Nilselid; Göteborgs universitet; []
   Nyckelord :Alzheimer s disease; clusterin; apolipoprotein J; SP-40; brain tissue; cerebrospinal fluid; glycosylation; biomarker; enzyme-linked immunosorbent assay;

   Sammanfattning : The apolipoprotein clusterin is suggested to be involved in the pathogenesis of Alzheimer¡¦s disease (AD). At the start of these studies, results had indicated that clusterin was elevated in AD brain, compared with controls. LÄS MER

5. 4. Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders

   Författare :Therese Fagerqvist; Martin Ingelsson; Joakim Bergström; Lars Lannfelt; Michael G Schlossmacher; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha-synuclein; Parkinson´s disease; Lewy body dementia; Oligomer; Monoclonal antibody; Immunotherapy; Reactive aldehydes; Medical Science; Medicinsk vetenskap;

   Sammanfattning : The protein alpha-synuclein (α-synuclein) accumulates in the brain in disorders such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). It is believed that the monomeric form of α-synuclein can adopt a partially folded structure and start to aggregate and form intermediately sized oligomers or protofibrils. LÄS MER

7. 5. Genetic variation in genes involved in Abeta-degradation in Alzheimer disease

   Författare :Mia Blomqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alzheimer disease; SNPs; genotyping; association study; haplotype; linkage disequilibrium; association mapping;

   Sammanfattning : Alzheimer disease (AD) is a neurodegenerative disorder that causes dementia among mainly elderly people and is increasing in prevalence in industrialized societies from 1 to 3 % in 60-65 year-olds to as much as 50 % by age 95. This disease is complex. Multiple genes are involved, and they potentially affect each other. LÄS MER