Sökning: "Parkinson s Disease"

Visar resultat 6 - 10 av 55 avhandlingar innehållade orden Parkinson s Disease.

1. 6. Characterization of human dopaminergic neurons in the developing mesencephalon and upon differentiation of stem cells- for replacement therapy in Parkinson´s disease

   Författare :Jenny Nelander Wahlestedt; Utvecklings- och regenerativ neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson´s disease; stem cells; ventral mesencephalon; dopaminergic neurons; cell replacement therapy; human fetal tissue; radial glia; microRNA; BAC recombineering; reporter cell lines;

   Sammanfattning : Cell-replacement therapy is a promising approach for treating patients with Parkinson ́s disease (PD). For this purpose, there is a need for developing a protocol that can generate high numbers of human transplantable mesencephalic dopaminer- gic (mesDA) neurons. LÄS MER

3. 7. Parkinson's Disease with Device, Diary, or in Disguise. Dyskinesia reduction, motor state evaluation, and workforce participation among persons with Parkinson's disease

   Författare :Jonathan Timpka; Lund Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; Parkinson disease; Levodopa infusion; Motor fluctuations; Dyskinesia; Workforce participation; Work ability; Sickness absence; Employment; Patient reported outcome;

   Sammanfattning : INTRODUCTION: In the wait for disease-modifying treatment for Parkinson’s disease (PD), efforts towards improved symptom control and reduced negative effects of PD can result in meaningful change patients. The general efficacy of levodopa-carbidopa intestinal gel (LCIG) in advanced PD has been established, but its effects on dyskinesia need more investigation. LÄS MER

4. 8. Housing Matters for People with Parkinson´s disease. Accessibility, Meaning, Control and Activities of Daily Living

   Författare :Nilla Andersson; Aktivt och hälsosamt åldrande; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinsons disease; Housing accessibility; Percieved housing; Activities of daily living ADL ; Occupational Therapy; Psychometric;

   Sammanfattning : Parkinson´s disease (PD) is one of the most common neurological diseases with both motor and non-motor symptoms that can be perceived as difficult to control despite medical treatment. This leads to several consequences in everyday life for example difficulties in activities of daily living (ADL), sometimes already at diagnosis. LÄS MER

5. 9. Cell and Gene Therapy for Parkinson's Disease: Therapeutic Effect and Modulation of Dyskinesias in the 6-OHDA Rat Model

   Författare :Thomas Carlsson; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Pharmacological sciences; pharmacognosy; pharmacy; neurofysiologi; Medicin människa och djur ; Neurology; neuropsychology; neurophysiology; Neurologi; Medicine human and vertebrates ; Parkinson?s disease; Serotonin; Tyrosine hydroxylase; Ventral mesenchephalon; Motor behavior; L-DOPA; GTP cyclohydrolase 1; Gene therapy; Dyskinesias; Cell transplantation; Dopamine; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : The main pathological feature in Parkinson's disease is the progressive loss of dopamine neurons in the midbrain, which in turn leads to the appearance of motor deficits such as akinesia/bradykinesia (loss/slowness of movements), rigidity, postural imbalance and tremor. To this day, there is no cure for the disease, but there are medications to relieve the symptoms. LÄS MER

7. 10. Cardiovascular disease in dementia

   Författare :Pavla Cermakova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The objective of this thesis was to characterize the burden of cardiovascular diseases in patients with dementia, their treatment and association with survival. Further, we aimed to explore whether cardiac structure in young adults can affect the aging brain. LÄS MER