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1. 1. RhoGTPase Signaling in Cell Polarity and Gene Regulation

   Författare :Ann-Sofi Johansson; Pontus Aspenström; Johan Lennartsson; Christer Larsson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; RhoGTPase; Par6; cell polarity; aPKC; epithelial cell; PDGF; gene regulation; microarray; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : RhoGTPases are proteins working as molecular switches as they bind and hydrolyze GTP. They are in their active conformation when GTP is bound and are then able to interact with their effector proteins, which relay the downstream signaling. When the GTP is hydrolyzed to GDP, the RhoGTPase is inactivated. LÄS MER