Sökning: "PapG adhesion"

Hittade 5 avhandlingar innehållade orden PapG adhesion.

  1. 1. Carbohydrate-Based Inhibitors of Pathogen Adhesion to Cell Surface Glycoconjugates

    Författare :Henrik C Hansen; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Galabiose analogs; Globotriose analogs; Escherichia coli; verotoxin; PapG adhesion; Streptococcus suis; Dendrimers; Multivalency; Amino-deoxy analogs; Organic chemistry; Inhibitor; Ceramide analogs; Glycoconjugates; Organisk kemi;

    Sammanfattning : The fact that a growing number of pathogens develop resistance against traditional treatment is a growing medical problem. Infections, which until now have been harmless, might turn into life threatening diseases. These problems have led to an intensified search for alternative treatments. Analogs of cell surface glycoconjugates are an alternative. LÄS MER

  3. 2. Potent inhibitors of uropathogenic E. coli papG adhesins; Synthesis, conformational studies and biological evaluation of galabiose derivatives and synthesis of glycosphingolipid analogues

    Författare :Jörgen Ohlsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Glycosphingolipid analogue; PapG adhesin; Esherichia coli; Galabiose analogues; Inhibitors; Glycoconjugates;

    Sammanfattning : The importance of carbohydrates in biological systems has become evident during the last fifty years. It is well known that pathogenic bacteria and viruses attach to glycoconjugates present at mammalian cell surfaces, and that this attachment is a prerequisite for the later stages of infection. LÄS MER

  4. 3. The importance of Escherichia coli fimbriae in urinary tract infection

    Författare :Mats Söderhäll; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Urinary tract infection (UTI) is a major bacterial infectious disease among women. Uropathogenic Escherichia coli is the most dominant causative agent. LÄS MER

  5. 4. Escherichia coli Fimbriae, Bacterial Persistence and Host Response Induction in the Human Urinary Tract

    Författare :Göran Bergsten; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mykologi; virologi; bakteriologi; Mikrobiologi; mycology; virology; bacteriology; Microbiology; IL-8; IL-6; neutrophils; GFP; mucosal host response; Type 1 fimbriae; P fimbriae; adherence; virulence factors; regulation; deliberate colonisation; Escherichia coli 83972; Urinary tract infection; asymptomatic bacteriuria;

    Sammanfattning : Urinary tract infections (UTI) are among the most common bacterial infections in humans. Symptomatic UTIs may be acute, recurrent or chronic but the most frequent form of UTI is asymptomatic bacteruria (ABU). In ABU, the mucosa remains inert, despite the presence of large bacterial numbers in urine. LÄS MER

  7. 5. Novel tools for the study and diagnosis of bacterial infections : exploring the intersection of microbiology and microfabrication

    Författare :Charalampos Antypas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The alarming increase in antibiotic resistance calls for new approaches to study and diagnose bacterial infections. In my thesis, I worked at the intersection of microbiology, microfabrication, and optical probes to develop novel diagnostic and screening assays for microbiology and elucidate bacterial pathogenesis in urinary tract infections (UTI). LÄS MER