Sökning: "Pancreatic carcinoma"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden Pancreatic carcinoma.

  1. 1. Pancreatic carcinoma in Malmö, Sweden: Clinical, epidemiological and biochemical aspects

    Författare :Mats Hedberg; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kirurgi; Pancreatic carcinoma; survival rate; epidemiology; incidence rate; risk factors; smoking; weight gain; gastric resection; cholecystokinin; Surgery; pancreatic enzymes; traumatology; traumatologi; ortopedi; orthopaedics;

    Sammanfattning : The objective of this thesis has been to assess whether there are indications suggesting that new methods for diagnosis and treatment of pancreatic carcinoma (PCa) has been followed by an improved prognosis, and to assess the possible role of smoking and gastric resection in the causation of the disease. Of the 1,200 new cases PCa diagnosed in Sweden yearly, the majority are older than 70 years, the case fatality rate being close to 100%. LÄS MER

  3. 2. Molecular Characterization of Genomic Amplifications in Pancreatic Cancer

    Författare :Markus Heidenblad; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FISH; Clinical genetics; PCR; cDNA microarray; array-based CGH; expression profiling; genomic profiling; Pancreatic cancer; gene amplification; Klinisk genetik;

    Sammanfattning : Pancreatic cancer includes multiple histologic subtypes that show large differences in their clinical and biological characteristics. Despite this diversity, more than 85% of the neoplasms in the organ are malignant ductal adenocarcinomas, which are the focus of the present thesis. LÄS MER

  4. 3. Assessment of diagnostic and prognostic factors in pancreatic duct carcinoma

    Författare :Stefan Linder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Pancreatic neoplasms; cytology; diagnosis; prognosis; DNA ploidy; morphometry; immunohistochemistry; Ki-67 antigen; p53 protein; ECM proteins; adhesion molecules.;

    Sammanfattning : The diagnosis pancreatic carcinoma is suggested by a combination of clinical and radiological signs. The differential diagnosis vs. chronic pancreatitis may, however, be difficult. Morphological verification of malignancy is therefore necessary before initiating non-surgical therapy. LÄS MER

  5. 4. Issues relevant to the endoscopic and surgical management of pancreatic carcinoma

    Författare :Farshad Frozanpor; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: A substantial proportion of the patients with pancreatic cancer require palliative decompression of the extrahepatic bile duct obstruction by endoscopic stent insertion. Only 20% of patients with pancreatic cancer are suitable for resection, which is considered to be a high-risk procedure with postoperative pancreatic fistula (PF) formation in a central role. LÄS MER

  7. 5. Molecular studies of pancreatic cancer: Characterization of the transforming growth factor beta signaling pathway

    Författare :Tord Jonson; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SMAD4; PCR; FISH; cytogenetics; chromosome; pancreatic cancer; TGFB signaling; cytogenetik; Genetik; Genetics;

    Sammanfattning : In the present thesis, genetic abnormalities in pancreatic cancer were studied, with special emphasis on alterations of components involved in the transforming growth factor beta (TGFB) signaling pathway. In the first study, fluorescence in situ hybridization and cytogenetic analyses revealed aberrations of chromosome 18 in all 13 pancreatic carcinoma cell lines studied, in particular frequent breaks close to the centromere of chromosome arm 18q. LÄS MER