Sökning: "Palladium-mediated reactions"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Palladium-mediated reactions.

  1. 1. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions PET Tracer Development Targeting the Vesicular Acetylcholine Transporter

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Roslin; Uppsala universitet.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Carbonylation; palladium; carbon-11; radiochemistry; positron emission tomography; vesicular acetylcholine transporter; vesamicol; alkyl halide; oxidative carbonylation; acylamidine; oxadiazole; heterocycle; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. LÄS MER

  2. 2. [11C]Carbon Monoxide in Rhodium-/Palladium-Mediated Carbonylation Reactions

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Julien Barletta; Uppsala universitet.; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; carbonylation reaction; carbon monoxide; PET; 11C-labelling; rhodium; palladium; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Sammanfattning : Methods for the 11C-labeling of carbonyl compounds applicable in the preparation of radiotracers for Positron Emission Tomography (PET) are described. To this end [11C]carbon monoxide at low concentration was used in transition metal- mediated reactions. LÄS MER

  3. 3. [11C]Carbon Monoxide and Aryl Triflates in Palladium-Mediated Carbonylation Reactions Synthetic approaches to [11C]Carbonyl Compounds and [11C]Amines

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Obaidur Rahman; Uppsala universitet.; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; [11C]Carbon monoxide; Aryl triflates; Carbonylation; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Sammanfattning : The usefulness of low concentrations (typically 10 to 100 µM) of [11C]carbon monoxide and aryl triflates as substrates in 11C-carbonylation using different nucleophiles in the presence of lithium bromide was investigated. The reactions were performed in a micro autoclave of 200 µL volume and catalysed (mediated) by palladium(0). LÄS MER

  4. 4. Copper and Palladium-Mediated Transformationsof Allylic and Propargylic Substrates

    Detta är en avhandling från Stockholm University

    Författare :Tony S. N. Zhao; Stockholms universitet.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis is focused on the development of new palladium and copper-mediated reactions for functionalization of alkenes and propargylic alcohol derivatives. We have developed an efficient procedure for the synthesis of allenyl and propargyl boronate from propargylic carbonates and acetates. LÄS MER

  5. 5. Design and Synthesis of Chalcone and Chromone Derivatives as Novel Anticancer Agents

    Detta är en avhandling från Stockholm University

    Författare :Christine Dyrager; Göteborgs universitet.; Gothenburg University.; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chalcones; Chromones; Fluorescence; Fluorophore; Cellular imaging; Anticancer; Tubulin; Microtubule; Kinase inhibitors; p38; MEK1; Palladium-mediated reactions; Molecular modeling; Structure-Activity Relationships.;

    Sammanfattning : This thesis comprises the design and synthesis of chalcone and chromone derivatives and their use in various biological applications, particularly as anticancer agents (targeting proteins associated with cancer pathogenesis) and as potential fluorophores for live-cell imaging. Conveniently, all structures presented were synthesized from commercially available 2 ́-hydroxyacetophenones. LÄS MER