Sökning: "Palladium-mediated reactions"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Palladium-mediated reactions.

  1. 1. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions : PET Tracer Development Targeting the Vesicular Acetylcholine Transporter

    Författare :Sara Roslin; Mats Larhed; Gunnar Antoni; Jonas Eriksson; Luke Odell; Victor Pike; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Carbonylation; palladium; carbon-11; radiochemistry; positron emission tomography; vesicular acetylcholine transporter; vesamicol; alkyl halide; oxidative carbonylation; acylamidine; oxadiazole; heterocycle; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. LÄS MER

  2. 2. [11C]Carbon Monoxide in Rhodium-/Palladium-Mediated Carbonylation Reactions

    Författare :Julien Barletta; Bengt Långström; Yu-Shin Ding; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; carbonylation reaction; carbon monoxide; PET; 11C-labelling; rhodium; palladium; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : Methods for the 11C-labeling of carbonyl compounds applicable in the preparation of radiotracers for Positron Emission Tomography (PET) are described. To this end [11C]carbon monoxide at low concentration was used in transition metal- mediated reactions. LÄS MER

  3. 3. [11C]Carbon Monoxide and Aryl Triflates in Palladium-Mediated Carbonylation Reactions : Synthetic approaches to [11C]Carbonyl Compounds and [11C]Amines

    Författare :Obaidur Rahman; Bengt Långström; Fredrik Almqvist; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; [11C]Carbon monoxide; Aryl triflates; Carbonylation; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : The usefulness of low concentrations (typically 10 to 100 µM) of [11C]carbon monoxide and aryl triflates as substrates in 11C-carbonylation using different nucleophiles in the presence of lithium bromide was investigated. The reactions were performed in a micro autoclave of 200 µL volume and catalysed (mediated) by palladium(0). LÄS MER

  4. 4. Copper and Palladium-Mediated Transformationsof Allylic and Propargylic Substrates

    Författare :Tony S. N. Zhao; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis is focused on the development of new palladium and copper-mediated reactions for functionalization of alkenes and propargylic alcohol derivatives. We have developed an efficient procedure for the synthesis of allenyl and propargyl boronate from propargylic carbonates and acetates. LÄS MER

  5. 5. Synthesis of ethyne-linked porphyrin systems using palladium-mediated cross-coupling reactions

    Författare :Johan Kajanus; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER