Sökning: "Pain models"

Visar resultat 1 - 5 av 167 avhandlingar innehållade orden Pain models.

1. 1. Chronic pain : from the study of student attitudes and preferences to the in vitro investigation of a novel treatment strategy

   Författare :Linda Rankin; Christopher J. Fowler; Gisselle Gallego; Sofia Mattsson; Emmanuel Bäckryd; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HC-PAIRS; best-worst scaling; palmitoylethanolamine; N-acylthanolamines; oral lichen planus; prostaglandins; chronic pain; prolonged pain; chronic pain education; chronic pain management; medical students; attitudes;

   Sammanfattning : Chronic pain will affect one in five adults during their lifetime, and it exerts a heavy burden on society with major physiological, psychological, social, and economic impacts. The current chronic pain curriculum taught to medical students in most settings is fragmented, inconsistent and inadequate and a vast majority of general practitioners considered their undergraduate training in chronic pain incomplete. LÄS MER

3. 2. Back pain : long-term course and predictive factors

   Författare :Paul Enthoven; Peter Croft; Linköpings universitet; []
   Nyckelord :back pain; MEDICINE; MEDICIN;

   Sammanfattning : Background. Better knowledge of the long-term course in patients treated in primary care for back pain (clinical course) and in patients that do not receive specific treatment after seeking care (clinical natural course) is needed to enable health professionals and their patients to understand the likely course of back pain and to make clinical decisions about treatment alternatives. LÄS MER

4. 3. Interactions with pain-related systems - Towards new electrical treatments for chronic pain

   Författare :Matilde Forni; NanoLund: Centre for Nanoscience; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High definition brain stimulation; Periaqueductal gray matter; Pain systems; Pain models;

   Sammanfattning : Background. Persistent intolerable pain is still an unsolved issue with a huge socioeconomic impact. To develop appropriate treatments, it is crucial to understand the complex mechanisms underlying pain and how they change during sustained pain stimuli or during pathological conditions. LÄS MER

5. 4. Development of Substance P 1–7 Related Peptides and Peptidomimetics : Targeting Neuropathic Pain

   Författare :Anna Skogh; Anja Sandström; Christian Sköld; Rebecca Fransson; Philip Thompson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance P 1–7; Peptidomimetics; Solid-phase Peptide Synthesis SPPS ; Palladium catalysis; Carbonylation; Imidazole; Bioisostere; Neuropathic pain; Allodynia; Structure-activity relationships; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : The neuropeptide substance P 1–7 (SP1–7, H-Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-OH) and its amidated analogue SP1–7 amide, have displayed intriguing effects in experimental models for neuropathic pain acting on a specific, yet unknown SP1–7 target. The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area. LÄS MER

7. 5. Sensorimotor characteristics in chronic neck pain : possible pathophysiological mechanisms and implications for rehabilitation

   Författare :Peter Michaelson; Gwendolyn Jull; Umeå universitet; []
   Nyckelord :Outcome prediction; Pain intensity; Neck Pain; WAD; Motor control; Proprioception; Balance; Cervical stability; Jerk; Neck kinematics; kirurgi; Surgery;

   Sammanfattning : Pain from the musculoskeletal system is very common in the modern society. Chronic musculoskeletal pain syndromes causes not only individual suffering but also dysfunctions of movements and postural control, as large costs for the society. LÄS MER