Sökning: "PacBio"
Visar resultat 6 - 10 av 10 avhandlingar innehållade ordet PacBio.
6. Genomics of Plasmodiophora brassicae
Sammanfattning : Plasmodiophora brassicae is a soil-borne pathogen that infects roots of plants in Brassicaceae and causes enlarged roots or clubs known as the clubroot disease. Details of its complex life cycle and particularly the molecular basis of its strategies to master defenses and alter metabolism of plant hosts are still largely unknown. LÄS MER
7. Culture-independent methods and high-throughput sequencing applied to evolutionary microbial genomics
Sammanfattning : Culture-independent methods allow us to better understand the diversity of microorganisms on earth. By omitting the culturing step, we can gain access to species previously out of our reach.To better capture and understand the diversity of microorganisms, we have developed an alternative to 16S amplicon sequencing. LÄS MER
8. Bridging the past to the present: investigating species boundaries with herbarium specimens and next-generation-sequencing. A case study of circumpolar Silene sect. Physolychnis
Sammanfattning : During the recent decades, genetic information enclosed in herbarium collections have been partly revealed, largely due to the fast-moving high-throughput sequencing technologies. However, the genetic outcome from herbarium material is limited by its degradation over time, often worsened by certain preservation methods. LÄS MER
9. Trypanosoma cruzi genome plasticity and evolution
Sammanfattning : Trypanosoma cruzi, a protozoan from the Kinetoplastidae family, is the etiologic agent of Chagas disease, a major public health problem affecting mostly the poorest areas of Latin America. Due to the complex nature of the parasite’s genome it has been impossible to produce a complete reference genome sequence, thus hampering the implementation of post- genomic approaches to unveil the mechanisms of generation of antigenic variation and the identification of new drug targets. LÄS MER
10. Diverse cyclic dinucleotide signals regulate Escherichia coli lifestyle transition
Sammanfattning : Bacteria have the ability to change their lifestyle to adapt to various environmental conditions. Cyclic dinucleotides (cDNs) are ubiquitous second messengers that can regulate fundamental lifestyle switches, such as motility versus sessility and acute versus chronic virulence, in bacteria. LÄS MER