Sökning: "PYK2"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet PYK2.

1. 1. Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2

   Författare :Inga Dikic; Olli Silvennoinen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Protein phosphorylation; tyrosine kinase; Pyk2 FAK; neuronal differentiation; Ras MAP kinase pathway; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : The proline-rich tyrosine kinase (Pyk2) together with focal adhesion kinase (FAK) define a family of non-receptor protein tyrosine kinases that are regulated by diverse stimuli. Activation of Pyk2 has been implicated in multiple signaling events, including modulation of ion channels, activation of MAP kinase cascades and apoptotic cell death. LÄS MER

3. 2. Regulation of the myogenic response and stretch-induced calcium signaling in the vascular wall: Novel insights into the role of microRNAs and protein tyrosine kinase 2

   Författare :Anirban Bhattachariya; Kärlfysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; portal vein; resistance artery; myogenic tone; PYK2; calcium; microRNA;

   Sammanfattning : Intraluminal pressure has a significant impact on vascular adaptability, phenotype and regulation of blood flow and pressure. On one hand, increased pressure/stretch for a prolonged time can cause structural changes in vessel wall; on the other hand, lack of pressure/stretch can promote a phenotype shift. LÄS MER

4. 3. Vascular smooth muscle mechanotransduction and plasticity-the role of microRNA, calcium signaling and actin polymerization

   Författare :Karolina Turczynska; Kärlfysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PYK2; actin polymerization; calcium; microRNA; stretch;

   Sammanfattning : Smooth muscle cells residing in the blood vessel media are constantly exposed to mechanical forces exerted by the intraluminal pressure. The smooth muscle senses and adapts to mechanical forces by activation of multiple signaling pathways and cytoskeletal rearrangements. LÄS MER

5. 4. Pro- and anti-inflammatory regulation of β2 integrin signalling in human neutrophils

   Författare :Veronika Brodin Patcha; Eva Särndahl; Emmanuelle Caron; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; inflammation; neutrophils; signalling; integrins; Cell biology; Cellbiologi;

   Sammanfattning : The body is under constant attack from pathogens trying to slip by our immune defence. If the barrier is breached, invading pathogens enter the tissues and cause inflammation. During this process neutrophils, constituting the first line of defence, leave the bloodstream and seek out and kill the invading pathogens. LÄS MER

7. 5. Ubiquitination and Receptor Endocytosis

   Författare :Kaisa Haglund; Carl-Henrik Heldin; Ivan Dikic; Harald Stenmark; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Ubiquitination; receptor tyrosine kinase; endocytosis; Cbl; CIN85; EGFR; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : Protein ubiquitination is an evolutionary conserved mechanism that controls a wide variety of cellular functions. Polyubiquitinated proteins are generally degraded in the proteasome, whereas monoubiquitination controls various other cellular processes, including endocytosis and endosomal sorting. LÄS MER