Sökning: "PTMs"

Visar resultat 6 - 10 av 29 avhandlingar innehållade ordet PTMs.

1. 6. HMGB1 : regulation of inflammatory functions and therapeutic blockade

   Författare :Peter Lundbäck; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The intracellular protein High Mobility Group Box Protein 1 (HMGB1) has been identified as a pivotal mediator of inflammation. HMGB1 can be released by various mechanisms and as an inflammatory mediator it induces both migration of inflammatory cells and cytokine production. LÄS MER

3. 7. Development of DNA-based methods for analysis of protein interactions

   Författare :Axel Klaesson; Ola Söderberg; Mats Nilsson; Cristina Al-Khalili Szigyarto; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; In situ proximity ligation assay PLA ; rolling circle amplification RCA ; Hybridization chain reaction HCR ; proxHCR; Oligonucleotide design; Protein-protein interactions; Post-translational modifications.; Farmaceutisk vetenskap; Pharmaceutical Science; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : In situ proximity ligation assay (PLA) is a method for detection of protein interactions, post-translational modifications (PTMs) and individual proteins that allows information about their localization in a cell or tissue to be extracted. The method is based on oligonucleotide-conjugated antibodies (proximity probes) that upon binding of two epitopes in close proximity give rise to an amplifiable DNA circle. LÄS MER

4. 8. Role of Neuroinflammation in Parkinson's Disease and Related Disorders

   Författare :Edoardo Brandi; Neural plasticitet och reparation; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha synuclein; Preformed fibrils; Microglia; Astrocyte; Neuroinflammation; Lipopolysaccharides; Parkinson Disease; Lewy Body Dementia; Multiple system atrophy; Synucleinopathies;

   Sammanfattning : Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates, progressive neurodegeneration, and neuroinflammation. Alpha-synuclein (a-syn) is the principal component of intracellular aggregates and can be modified by several mutations and post-translational modifications (PTMs), which can alter the protein structure affecting its aggregation, toxicity, and ability to spread. LÄS MER

5. 9. Precision mass measurements : Final limit of SMILETRAP I and the developments of SMILETRAP II

   Författare :Andreas Solders; Reinhold Schuch; Juha Äystö; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SMILETRAP; Precision mass spectrometry; Penning trap; Atomic mass; Highly charged ions; Low energy ion storage; Time of flight ion cyclotron resonance; High frequency; Proton mass; QED; g-factor; Physics; Fysik; Physics; fysik;

   Sammanfattning : The subject of this thesis is high-precision mass-measurements performed with Penning trap mass spectrometers (PTMS). In particular it describes the SMILETRAP I PTMS and the final results obtained with it, the masses of 40Ca and that of the proton. LÄS MER

7. 10. Ubiquitin, SUMO and PAR : deciphering recruitment signals at DNA damage sites

   Författare :Annika Pfeiffer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Protecting genome integrity is a vital task that is constantly challenged by various genotoxic stresses. Among different types of DNA damage, double-strand breaks (DSBs) constitute a particular threat since they result in the loss of integrity of both complementary DNA strands. LÄS MER