Sökning: "PTMs"

Visar resultat 21 - 25 av 29 avhandlingar innehållade ordet PTMs.

  1. 21. An exPADItion for citrullination in the developing hair follicle

    Författare :Kim Vikhe Patil; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During epidermal development, to assure proper tissue structure, highly complex transcriptional networks interact within the stem cell compartments of the epidermis and hair follicles (HFs) to balance the choice between self-renewal or differentiation. The full characterisation of the protein profiles resulting from those transcriptional networks, within the compartments of the HF, remains, however, incomplete. LÄS MER

  3. 22. Protein expression in prostate cancer

    Författare :Helena Lexander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Two-dimensional gel electrophoresis; protein expression; biomarker; Gleason grade; DNA-ploidy;

    Sammanfattning : The molecular pathology of prostate cancer (PCa) is complex and the pathways and the acquired molecular defects responsible for PCa initiation, development and progression are still largely unknown. Tumors of the prostate have an unpredictable behavior and in clinically detected cancers it is presently not possible to assess tumor aggressiveness. LÄS MER

  4. 23. New fractionation tools targeting elusive post-translational modifications

    Författare :Celina Wierzbicka; Malmö högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular imprinting; Molecular recognition; Phosphopeptides; Proteomics; Phosphotyrosine; Phosphohistidine;

    Sammanfattning : Protein phosphorylation is a reversible post-translational modification (PTM)playing a central role in numerous biological events including disease pathogenesis.Thus, the analysis of phosphoproteome is crucial for understandingcellular regulation processes and can facilitate the development of new diagnosticand therapeutic tools. LÄS MER

  5. 24. Chemical proteomics for drug target deconvolution and to study biological systems

    Författare :Christian M Beusch; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mass spectrometry-based proteomics has become an irreplaceable method for the unbiased and system-wide study of protein chemistry. As modern proteomics methods can not only be applied to quantify protein expression levels, but also monitor changes in post-translational modifications, subcellular localization, turnover rate, and lastly protein structures, it has become a method of choice for drug discovery and dissecting cellular processes. LÄS MER

  7. 25. The role of SUMO pathway in pathophsiology of skeletal muscle

    Författare :Arvind Venkat Namuduri; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscles are highly evolved and essential organs comprising 40 % of the total human body weight. They are essential in maintaining posture, energy metabolism, secrete hormones and act as central reserves for amino acids. LÄS MER