Sökning: "PTMs"

Visar resultat 11 - 15 av 29 avhandlingar innehållade ordet PTMs.

  1. 11. Post-translational modifications of myelin oligodendrocyte glycoprotein in CNS autoimmunity

    Författare :Andreas Warnecke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmunity towards components of the central nervous system (CNS) is a driving factor of nerve demyelination in Multiple Sclerosis (MS). The etiology of autoimmunity in MS pathogenesis remains elusive, but a combination of genetic predisposition and environmental triggers is theorized to initiate this complex disease. LÄS MER

  3. 12. Synthesis and investigation of bacterial effector molecules

    Författare :Michael Franz Albers; Christian Hedberg; Christian Hackenberger; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bacterial effectors; organic synthesis; Legionella; PTM; peptide synthesis; nucleotide chemistry; Biorganic Chemistry; bioorganisk kemi;

    Sammanfattning : During infections, bacterial microorganisms initiate profound interactions with mammalian host cells. Usually defense mechanisms of the host destroy intruding bacteria in rapid manner. However, many bacterial pathogens have evolved in a way to avoid these mechanisms. LÄS MER

  4. 13. Epigenomic landscape of Arabidopsis thaliana

    Författare :Trejo Minerva; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The basal unit of information storage in the cell is at the level of the DNA sequence. Dynamic packaging of DNA into chromatin allows additional regulatory layers. Two pairs of each histones H3, H4, H2A and H2B constitute an octamer around which about 146 base pairs of DNA are wrapped to build the basic unit of chromatin: the nucleosome. LÄS MER

  5. 14. Improvements and Applications of in situ Proximity Ligation Assays

    Författare :Karin Grannas; Ola Söderberg; Christer Wingren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molekylär medicin; Molecular Medicine;

    Sammanfattning : The cells building up the human body is in constant communication with each other. This communication is done through large complex networks of signaling pathways for inter- and intracellular signal transduction. The signaling activity regulates many important processes, for example cell death, proliferation and differentiation. LÄS MER

  7. 15. Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay

    Författare :Linda Arngården; Ola Söderberg; Niclas Karlsson; Uppsala universitet; []
    Nyckelord :cell signaling; Wnt; Hippo; TGFB; Molekylär medicin; Molecular Medicine;

    Sammanfattning : A cell that senses signals from its environment uses proteins for signal transduction via post translational modifications (PTMs) and protein- protein interactions (PPIs) from cell membrane into the nucleus where genes controlling cell proliferation, differentiation and apoptosis can be turned on or off, i.e. LÄS MER