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Visar resultat 1 - 5 av 23 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Glucose- and hypoxia-regulated insulin gene expression

    Författare :Linda Tillmar; Jens Höiriis Nielsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; islet; beta-cell; insulin; mRNA stability; PTB; glucose; hypoxia; mTOR; p70s6k; ceramide; redox; ROS; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Although extensively studied, there are still many unanswered questions regarding the exact regulation of insulin gene expression. This is important to further investigate since it will hopefully help us understand the pathophysiology of some types of diabetes. LÄS MER

  3. 2. Rewiring ret : PTB-adaptor regulated signaling and cell biology

    Författare :T Kalle Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Ret receptor belongs to a group of transmembrane tyrosine kinase receptors that serve to transduce environmental signals into cellular responses. Upon extracellular ligand activation the receptors dimerize and their structural conformation is altered into one that allows for interaction with proteins in the cell cytosol. LÄS MER

  4. 3. Gender matters : understanding of access barriers to community-based tuberculosis care in Bangladesh

    Författare :Fazlul Karim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Community-based DOTS programme; Bangladesh; Gender; Delays; Stigma; Cultural epidemiology; Socio-economic divides; Smear-positive PTB prevalence;

    Sammanfattning : Background: Females lesser use of TB control services is a grave concern worldwide, entailing more gender research in quest of practical remedies. Objective: To understand the gender differences in various clinical steps for TB care, explore gender-specific access barriers to TB control; and measure smear-positive PTB prevalence in different population groups of rural Bangladesh. LÄS MER

  5. 4. Preterm birth : parents' experiences, affect, stress and inflammatory markers

    Författare :Emma Fransson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Preterm birth (PTB), before 37 completed weeks of gestation, is the principal risk factor for neonatal morbidity and mortality. In Sweden about 5.6% of pregnant women deliver preterm. The etiology of PTB is not fully understood, but it has been suggested that the underlying mechanisms could have both biological and psychosocial origins. LÄS MER

  7. 5. Prediction of Spontaneous Preterm Birth : Clinical and Immunological Aspects

    Författare :Maria Svenvik; Jan Ernerudh; Marie Blomberg; Maria Jenmalm; Teresa Cobo; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Background: Preterm birth (PTB), defined as birth before 37 weeks of gestation, accounts for most neonatal death and morbidity. Accurate prediction is a pre-requisite for the prevention and proper management of PTB. However, methods for prediction are unsatisfactory, although sonographic cervical length has a moderate predictive value. LÄS MER