Sökning: "PS1"

Visar resultat 1 - 5 av 24 avhandlingar innehållade ordet PS1.

  1. 1. TRAF6, a key regulator of TGFβ-induced oncogenesis in prostate cancer

    Författare :Reshma Sundar; Marene Landström; Carl-Henrik Heldin; Petra Knaus; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TβRI; TGFβ; TACE; TRAF6; PS1; PKCζ; TβRI-ICD; NICD; Smad; non-Smad; prostate cancer; Snail1; MMP; p300; p21; PAI1; ubiquitination; cleavage; ICD; invasion; HES1; signaling; patologi; Pathology;

    Sammanfattning : Prostate cancer is the most common cancer in men, with the incidence rapidly increasing in Europe over the past two decades. Reliable biomarkers for prostate cancer are currently unavailable. Thus, there is an urgent need for improved biomarkers to diagnose prostate cancer at an early stage and to determine the best treatment options. LÄS MER

  3. 2. Cell death and signal transduction pathways in Alzheimer's disease : the role of presenilin 1

    Författare :Bogdan O Popescu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mutated presenilins (PSs) may cause familial Alzheimer's disease (FAD) by altering neuronal signal transduction pathways, by increasing AP production or by triggering a number of proapoptotic mechanisms. The present thesis explores mechanisms by which PSs regulate signal transduction and cell death with relevance to AD. LÄS MER

  4. 3. Functional domains in the Alzheimer's disease-associated presenilin 1 protein

    Författare :Hanna Laudon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD), the most common cause of dementia, is neuropathologically characterized by the presence of neurofibrillary tangles and amyloid plaques in the brain. Amyloid plaques are extracellular deposits primarily composed of the amyloid beta-peptide (Abeta). LÄS MER

  5. 4. Studies of presenilin function in neurodegeneration and in human embryonic CNS during development

    Författare :Beata Kostyszyn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity for cleaving transmembrane proteins such as the amyloid precursor protein (APP), Notch receptors and ligands. LÄS MER

  7. 5. Alzheimer disease associated Abeta and gamma-secretase : mitochondrial localization and involvement in cell death

    Författare :Camilla Hansson Petersen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In several neurodegenerative disorders, including Alzheimer disease (AD) and Parkinson disease (PD), protein aggregation is accompanied by mitochondrial dysfunction. An increasing number of proteins found in mitochondria have multiple localizations. LÄS MER