Sökning: "PPAR"

Visar resultat 21 - 25 av 33 avhandlingar innehållade ordet PPAR.

  1. 21. Metabolic Significance of Fatty Acid Elongation

    Författare :Damir Zadravec; Anders Jacobsson; Douglas Tocher; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Fysiologi; fysiologi; Physiology;

    Sammanfattning : Very long-chain fatty acids (VLCFAs), including polyunsaturated fatty acids (PUFAs), are essential lipids whose functional diversity is made possible by variation in their chain length and degree of unsaturation. Fatty acids can either be derived directly from the diet or they can be synthesized de novo through lipogenesis, up to 16 carbons in length by fatty acid synthase. LÄS MER

  3. 22. Growth hormone regulation of LFABP and PPARa. Genes involved in hepatic lipid metabolism

    Författare :Linda Carlsson; Göteborgs universitet; []
    Nyckelord :Growth hormone; fatty acids; rat; hepatocyte; LFABP; C EBPa; PPARa;

    Sammanfattning : Growth hormone (GH) is known to have several important effects in the control of metabolism. The aim of these studies was to investigate how GH regulates genes involved in fatty acid transport and metabolism in the liver and the interaction between GH and fatty acids in this regulation. LÄS MER

  4. 23. Post-transplantation Hypercholesterolaemia

    Författare :Osama Al Rayyes; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thiazolidinediones; transplantation; low density lipoprotein; insulin; indomethacin; hydrocortisone; fluvastatin; flufenamic acid; Cholesterol; cyclosporine; troglitazone.; Immunology; serology; Immunologi; serologi;

    Sammanfattning : The multidrug regimen, cyclosporine, corticosteroids, and azathioprine, is used in transplantation centres to prevent organ rejection. Several clinical studies have shown that cyclosporine and corticosteroids to cause increases in low density lipoprotein (LDL)-cholesterol, with subsequent development of atherosclerosis. LÄS MER

  5. 24. The role of PPARalpha and growth hormone in hepatic lipid metaboism and atherosclerosis

    Författare :Anna Ljungberg; Göteborgs universitet; []
    Nyckelord :growth hormone; PPARalpha; atherosclerosis; lipid metabolism; fatty acids; apoB; ; ADRP; triglycerides; PGC-1; liver;

    Sammanfattning : Dyslipidemia mainly results from oversecretion of apoB-containing lipoproteins from theliver and is one of the most important risk factors for the development of atherosclerosis.Growth hormone (GH) plays a key role in the regulation of lipoprotein metabolism and thus,disturbances in GH secretion are associated with dyslipidemia and cardiovascular disease. LÄS MER

  7. 25. Endotoxin-, glutamate- and drug-induced inflammation and cytotoxicity with emphasis on signal transduction mechanisms

    Författare :Ylva Edling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inflammatory cells such as monocytes and glial cells play an important role in the pathogenesis of ischemic- or drug-induced brain or liver injury. Excessive concentrations of glutamate is toxic to neural cells, and triggers a series of transcriptional events beginning with the expression of the immediate early genes like c-fos and c-jun, which in turn affect the expression of other genes necessary for the development of brain injury. LÄS MER