Sökning: "PPARã"

Visar resultat 6 - 10 av 11 avhandlingar innehållade ordet PPARã.

  1. 6. Peroxisome proliferator-activated receptor delta (PPARD) : molecular studies of regulation and activation

    Författare :Petra Thulin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors involved in energy homeostasis. Their natural ligands are fatty acids and there are three different PPAR isoforms; PPARA, PPARG and PPARD. LÄS MER

  3. 7. Role of GPS2 in epigenome alterations linked to metaflammation

    Författare :Zhiqiang Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein pathway suppressor 2 (GPS2) is a key component of the HDAC3 co-repressor complex that has been earlier implicated in cholesterol homeostasis and anti-inflammatory crosstalk. LÄS MER

  4. 8. Modulation of adaptive immune responses in mice upon exposure to peroxisome proliferators

    Författare :Qian Yang; Norbert Latruffe; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Sammanfattning : At present, there is an increasing awareness that exposure of mammals to drugs or other foreign chemicals can result in modulation of immunological responses via direct or indirect mechanisms. Changes in the immune system can obviously have profound physiological and pathological consequences. LÄS MER

  5. 9. The role of GH in the regulation of energy homeostasis, lipid metabolism and cardiovascular function in transgenic mice

    Författare :Bob Olsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth hormone; cardiovascular disease; energy homeostasis; lipid metabolism; transgenic mice;

    Sammanfattning : The aim of this thesis was, using two transgenic models, to investigate some metabolic diseases associated with acromegaly e.g. hypertension and alterations in lipid and lipoprotein metabolism. LÄS MER

  7. 10. Skeletal muscle metabolic flexibility : the roles of AMP-activated protein kinase and calcineurin

    Författare :Yun Chau Long; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; metabolism; glucose; lipid; gene expression; AMP-activated protein kinase; calcineurin; exercise;

    Sammanfattning : Skeletal muscle fibers differ considerably in their metabolic and physiological properties. The metabolic properties of skeletal muscle display a high degree of flexibility which adapts to various physiological demands by shifting energy substrate metabolism. LÄS MER