Sökning: "POSO"

Hittade 4 avhandlingar innehållade ordet POSO.

  1. 1. Structure-Based Virtual Screening : New Methods and Applications in Infectious Diseases

    Författare :Micael Jacobsson; Anders Karlén; Mats Kihlén; Antti Poso; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; : drug discovery; docking; scoring; virtual screening; malaria; tuberculosis; Pharmaceutical chemistry; Läkemedelskemi;

    Sammanfattning : A drug discovery project typically starts with a pharmacological hypothesis: that the modulation of a specific molecular biological mechanism would be beneficial in the treatment of the targeted disease. In a small-molecule project, the next step is to identify hits, i.e. molecules that can effect this modulation. LÄS MER

  3. 2. Design strategies for new drugs targeting multicomponent systems : focusing on class II MHC proteins and acetylcholinesterase

    Författare :Cecilia Lindgren; Anna Linusson; Antti Poso; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; class II MHC protein; drug design; molecular dynamics simulation; multicomponent system; nerve agent; oxime; quantitative structure-activity relationship; reactivator; rheumatoid arthritis; statistical molecular design; T-cell receptor;

    Sammanfattning : The field of medicinal chemistry is constantly evolving. Aided by advances within techniques as well as knowledge of biological systems, increasingly complex targets and drugs can be considered. LÄS MER

  4. 3. Computational Modelling in Drug Discovery : Application of Structure-Based Drug Design, Conformal Prediction and Evaluation of Virtual Screening

    Författare :Martin Lindh; Anders Karlén; Antti Poso; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery; docking; virtual screening; tuberculosis; conformal prediction;

    Sammanfattning : Structure-based drug design and virtual screening are areas of computational medicinal chemistry that use 3D models of target proteins. It is important to develop better methods in this field with the aim of increasing the speed and quality of early stage drug discovery. LÄS MER

  5. 4. Introduction of POSO concept by WILO AB and its Benefits for the Company

    Författare :Wojciech Wielgosz; Anna Tourlova; Christine Lundberg; Jerzy Kociatkiewicz; Lauranne Fina Tyttie Luc Emilie Venezia; Växjö universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; POSO; WILO; Service; service management; customer relation management; Economics; Nationalekonomi;

    Sammanfattning : The Swedish branch of the WILO Group and the daughter of the WILO AG, which is one of the biggest producer of pumps worldwide, is going to introduce a new business organization concept in Sweden and evolve the present company's structure into a more customer-oriented one (Project-Oriented-Service-Organization) based on the experiences of the parental company in Germany – WILO AG.A new service approach is going to be introduced by a company, which deals with business-to-business customers. LÄS MER