Sökning: "PON1"

Hittade 4 avhandlingar innehållade ordet PON1.

  1. 1. Computational Modeling of the Mechanisms and Selectivity of Organophosphate Hydrolases

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Miha Purg; Uppsala universitet.; [2018]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Organophosphate Hydrolase; Computational enzymology; MPH; DFPase; PON1; Empirical Valence Bond; EVB;

    Sammanfattning : Computational modeling is becoming an increasingly integral part of (bio)chemistry, providing a powerful complementary view into the dynamics, binding, and reactivity of biochemical systems. In particular, molecular simulations based on multiscale models are now regularly employed in studies of enzymatic reactions, offering invaluable mechanistic insight through the lens of molecular energy landscapes. LÄS MER

  2. 2. Genes Involved in Parkinson's Disease - Focus on Mitochondrial and Detoxifying Enzymes

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Neuroscience

    Författare :Anna Anvret; Karolinska Institutet.; Karolinska Institutet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Parkinson’s disease is a common progressive neurodegenerative disorder which mostly affects the elderly population, with a prevalence of more than 1.5% in the population over the age of 65 years. Clinical motor symptoms are mainly caused by degeneration of dopamine neurons in substantia nigra pars compacta. LÄS MER

  3. 3. On Parkinsons disease and schizophrenia : Case control studies, cellular localization and modelling of candidate genes

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Neuroscience

    Författare :Andrea Carmine; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetic; association; dopamine; Parkinson s disease; schizophrenia; retinoid; aldehyde; toxicity;

    Sammanfattning : The causes of many major neurodegenerative, neurodevelopmental and psychiatric diseases are unknown. This thesis has aimed at applying knowledge about the dopamine (DA) neuron system and other key systems to clinical material (DNA and post mortem brain tissue) collected from patients with Parkinson s disease (PD), schizophrenia (SZ) and controls, in order to decipher genetic risk factors. LÄS MER

  4. 4. On genes involved in common neurological disorders : focus on Parkinson's disease

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Neuroscience

    Författare :Caroline Ran; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Parkinson’s disease and migraine are complex neurological disorders and it is likely that a combination of genetic risk factors are involved in the etiology of both these diseases. Papers in this thesis investigate candidate genes in the search of genetic risk factors contributing to disease. LÄS MER