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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.
1. Mechanisms of therapy resistance in acute lymphoblastic leukemia
Sammanfattning : Acute lymphoblastic leukemia (ALL) is a highly aggressive pediatric cancer that can affect both B cells and T cells. The advent of new therapies has increased the cure rates for both B-ALL and T-ALL patients. However, some patients still experience relapse with a variable response to the treatment and display poor survival. LÄS MER
2. Cell cycle regulation and DNA damage response : a record of polo-like kinase 1 activity
Sammanfattning : Division and cell proliferation is an essence of life. A human cell has in its core a very simple yet a very complex machinery to coordinate cell cycle activities and events. LÄS MER
3. Targeting polo-like kinase 1 in pediatric leukemia
Sammanfattning : Acute lymphoblastic leukemia (ALL) is one of the most common cancers among children in the world, with almost 90% complete remission rate after the primary treatment. However, some patients are resistant to treatment and some relapse later. Moreover, existing treatments are toxic and induce life-long adverse effects. LÄS MER
4. Adhesion-dependent mechanisms regulating mitosis
Sammanfattning : Integrin-mediated cell adhesion is required for normal cell cycle progression during G1-S transition and for the completion of cytokinesis. Cancer cells have ability to grow anchorage-independently, but the underlying mechanisms and the functional significance for cancer development are unclear. LÄS MER
5. Mechanisms of multicellular drug resistance and novel approaches for targeted therapy in cancer
Sammanfattning : Dysregulated gene expression, due to genetic and epigenetic aberrations, as well as cancer cell-stroma interactions underlie both tumorigenesis and resistance to anti-cancer therapy. Although governed by common mechanisms, these features are unique to each individual tumor and therefore a personalized treatment regimen needs to be composed for each patient. LÄS MER